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TRHR and ARRB1
Data Source:
HPRD
(in vitro)
TRHR
ARRB1
Description
thyrotropin releasing hormone receptor
arrestin beta 1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Lysosomal Membrane
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Postsynaptic Density
Basolateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle Membrane
Pseudopodium
Cytoplasmic Vesicle
Dendritic Spine
Postsynaptic Membrane
Molecular Function
Thyrotropin-releasing Hormone Receptor Activity
Protein Binding
G Protein-coupled Receptor Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Enzyme Inhibitor Activity
GTPase Activator Activity
Insulin-like Growth Factor Receptor Binding
Protein Binding
Transcription Factor Binding
Estrogen Receptor Binding
Ubiquitin Protein Ligase Binding
Alpha-1A Adrenergic Receptor Binding
Alpha-1B Adrenergic Receptor Binding
Angiotensin Receptor Binding
Follicle-stimulating Hormone Receptor Binding
V2 Vasopressin Receptor Binding
AP-2 Adaptor Complex Binding
Clathrin Adaptor Activity
Ion Channel Binding
Protein Phosphorylated Amino Acid Binding
Arrestin Family Protein Binding
Biological Process
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Activation Of MAPK Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
G Protein-coupled Receptor Internalization
Positive Regulation Of Receptor Internalization
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Protein Transport
Protein Ubiquitination
Histone Acetylation
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Interleukin-8 Production
Negative Regulation Of GTPase Activity
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Rho Protein Signal Transduction
Positive Regulation Of Histone Acetylation
Response To Drug
Follicle-stimulating Hormone Signaling Pathway
Stress Fiber Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Membrane Organization
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Histone H4 Acetylation
Pathways
Peptide ligand-binding receptors
G alpha (q) signalling events
Activated NOTCH1 Transmits Signal to the Nucleus
G alpha (s) signalling events
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Thrombin signalling through proteinase activated receptors (PARs)
Activation of SMO
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Protirelin
Diseases
GWAS
Body mass (lean) (
19268274
)
Daytime sleep phenotypes (
27126917
)
LDL cholesterol levels (
32203549
)
Night sleep phenotypes (
27126917
)
Pulse pressure (
30224653
)
Type 2 diabetes (
30297969
)
Obstructive sleep apnea trait (average respiratory event duration) (
26977737
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Interacting Genes
19 interacting genes:
ARRB1
C1QL4
COMT
EFNA5
FAM241B
FXYD6-FXYD2
GJB2
IER3IP1
NIPAL4
PEDS1-UBE2V1
SLC39A2
SLC39A9
SLC41A1
TMEFF2
TMEM218
TMEM239
TRH
UBE2J1
YIPF6
56 interacting genes:
ADH6
ADRB1
ADRB2
AGTR1
AP2B1
ARF6
BAG1
BTK
C5AR1
CCR5
CDC42
CLTC
CSK
CXCR2
CYTH2
DVL1
DVL2
FGR
FLNA
GNB1
GNMT
GPR50
GRK2
GSK3B
HCK
HCRTR1
JUN
LIMK1
MAP2K3
MAP2K4
MAP3K5
MAPK1
MAPK10
MAPK3
MAPK9
MDM2
NEK6
NFKBIA
NSF
OPRD1
PDE4D
PIK3R2
POT1
POU2F1
PRDM16
PRKN
PTH1R
PTHLH
RALGDS
RPL15
SASH1
SLC9A5
SREBF2
STAM
TRHR
ZBTB43
Entrez ID
7201
408
HPRD ID
11767
00146
Ensembl ID
ENSG00000174417
ENSG00000137486
Uniprot IDs
P34981
B7Z1Q3
P49407
PDB IDs
2IV8
6PWC
6TKO
6UP7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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