TPT1 and MLC1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TPT1	MLC1
Description		tumor protein, translationally-controlled 1	modulator of VRAC current 1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Extracellular Space Nucleus Cytoplasm Multivesicular Body Cytosol Cytoplasmic Microtubule Extracellular Exosome	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Integral Component Of Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Response To Virus Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Cellular Response To Cholesterol Caveolin-mediated Endocytosis
Pathways
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
GWAS		Type 2 diabetes ( 25760438)	Acne (severe) ( 24927181) Body mass index (adult) ( 28430825)
Interacting Genes		30 interacting genes: APP ATP1A1 ATP1A2 BCL2L1 CALM1 DBN1 EEF1A1 EEF1A2 EEF1B2 EEF1D FANCA HSPB1 IKBKG LIG4 MCL1 MCPH1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 RPLP1 SNX6 SPP1 STEAP3 TRIP13 TUBB2A VHL	6 interacting genes: DAPK2 KDM1A MYLK PRMT6 ROCK1 TPT1
Entrez ID		7178	23209
HPRD ID		15979	05800
Ensembl ID		ENSG00000133112	ENSG00000100427
Uniprot IDs		A0A024RDY2 A0A0B4J2C3 A0A0P1J1R0 P13693	A0A024R4V4 Q15049
PDB IDs		1YZ1 2HR9 3EBM 4Z9V 5O9L 5O9M 6IZB 6IZE
Enriched GO Terms of Interacting Partners?
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