MLC1 and DAPK2

Data Source:
HPRD (in vitro)

		MLC1	DAPK2
Description		modulator of VRAC current 1	death associated protein kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Integral Component Of Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome	Nucleus Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Autophagosome Lumen Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding	Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Cellular Response To Cholesterol Caveolin-mediated Endocytosis	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Eosinophil Chemotaxis Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Caspase activation via Dependence Receptors in the absence of ligand
Drugs			Fostamatinib
Diseases		Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
GWAS		Acne (severe) ( 24927181) Body mass index (adult) ( 28430825)	Arterial stiffness index ( 31235810) Blood protein levels ( 28240269) Cerebral amyloid deposition (PET imaging) ( 30361487) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) HDL cholesterol levels ( 32203549) Platelet distribution width ( 27863252) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Triglyceride levels ( 31647587) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		6 interacting genes: DAPK2 KDM1A MYLK PRMT6 ROCK1 TPT1	6 interacting genes: APP CAMK2A CCDC91 FAM9B MLC1 TGFBR1
Entrez ID		23209	23604
HPRD ID		05800	09905
Ensembl ID		ENSG00000100427	ENSG00000035664
Uniprot IDs		A0A024R4V4 Q15049	A0A024R603 Q9UIK4
PDB IDs			1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE 6PAW
Enriched GO Terms of Interacting Partners?
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