TPP2 and FBXL17

Data Source:
BioGRID (two hybrid)

		TPP2	FBXL17
Description		tripeptidyl peptidase 2	F-box and leucine rich repeat protein 17
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Nuclear Body	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Tripeptidyl-peptidase Activity Identical Protein Binding	Protein Binding
	Biological Process	Protein Polyubiquitination Proteolysis	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Nervous System Development Regulation Of Smoothened Signaling Pathway Neural Crest Cell Differentiation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Red cell distribution width ( 32888494)	Adult body size ( 32376654) Bipolar disorder (body mass index interaction) ( 24322204) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Carotid intima media thickness x smoking interaction ( 32117412) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31015462) Experiencing mood swings ( 29500382) Eye color ( 23118974) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29235454) Irritable mood ( 29500382) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neurociticism ( 29500382) Number of children ever born ( 27798627) Pulse pressure ( 30224653) Response to amphetamines ( 22952603) Smoking status (ever vs never smokers) ( 30643258) Weight ( 28552196)
Interacting Genes		5 interacting genes: EHHADH FBXL17 MTNR1A POLB PPP1R16A	42 interacting genes: ACSBG2 AK9 C21orf91 CCSER1 CFAP58 CLPX COG2 ETFA FILIP1L HADH IDO1 IFT46 KBTBD8 KLHL12 KLHL7 MED14 METAP2 OLR1 PCCB PHF7 PPP3CB PRMT1 PSME4 PXYLP1 RLF SCG5 SCPEP1 SRBD1 SUFU TASP1 TGFBI TMEM126A TMOD1 TPP2 UAP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 USP25 ZMYM2 ZNF350
Entrez ID		7174	64839
HPRD ID		01834	10950
Ensembl ID		ENSG00000134900	ENSG00000145743
Uniprot IDs		P29144 Q5VZU9	Q9UF56
PDB IDs			6W66 6WCQ
Enriched GO Terms of Interacting Partners?
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