FBXL17 and HADH

Data Source:
BioGRID (two hybrid)

		FBXL17	HADH
Description		F-box and leucine rich repeat protein 17	hydroxyacyl-CoA dehydrogenase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	3-hydroxyacyl-CoA Dehydrogenase Activity Transferase Activity Identical Protein Binding NAD+ Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Nervous System Development Regulation Of Smoothened Signaling Pathway Neural Crest Cell Differentiation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle	Fatty Acid Beta-oxidation Regulation Of Insulin Secretion Positive Regulation Of Cold-induced Thermogenesis
Pathways			Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs			NADH Acetoacetyl-CoA 3-Hydroxybutyryl-Coenzyme A Omega-3-carboxylic acids
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Adult body size ( 32376654) Bipolar disorder (body mass index interaction) ( 24322204) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Carotid intima media thickness x smoking interaction ( 32117412) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31015462) Experiencing mood swings ( 29500382) Eye color ( 23118974) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29235454) Irritable mood ( 29500382) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neurociticism ( 29500382) Number of children ever born ( 27798627) Pulse pressure ( 30224653) Response to amphetamines ( 22952603) Smoking status (ever vs never smokers) ( 30643258) Weight ( 28552196)	Amyotrophic lateral sclerosis (sporadic) ( 24529757)
Interacting Genes		42 interacting genes: ACSBG2 AK9 C21orf91 CCSER1 CFAP58 CLPX COG2 ETFA FILIP1L HADH IDO1 IFT46 KBTBD8 KLHL12 KLHL7 MED14 METAP2 OLR1 PCCB PHF7 PPP3CB PRMT1 PSME4 PXYLP1 RLF SCG5 SCPEP1 SRBD1 SUFU TASP1 TGFBI TMEM126A TMOD1 TPP2 UAP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 USP25 ZMYM2 ZNF350	8 interacting genes: ADH1A APP CDC42 CLK1 FBXL17 FBXO7 SLC2A4 STAT1
Entrez ID		64839	3033
HPRD ID		10950	08372
Ensembl ID		ENSG00000145743	ENSG00000138796
Uniprot IDs		Q9UF56	A0A140VK76 B3KTT6 Q16836
PDB IDs		6W66 6WCQ	1F0Y 1F12 1F14 1F17 1IL0 1LSJ 1LSO 1M75 1M76 2HDH 3HAD 3RQS
Enriched GO Terms of Interacting Partners?
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