TPH1 and YWHAH

Data Source:
HPRD (in vitro)

		TPH1	YWHAH
Description		tryptophan hydroxylase 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
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GO Annotations	Cellular Component	Cytosol Neuron Projection	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Extracellular Exosome
	Molecular Function	Tryptophan 5-monooxygenase Activity Iron Ion Binding Protein Binding	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Identical Protein Binding Ion Channel Binding Protein Heterodimerization Activity
	Biological Process	Circadian Rhythm Aromatic Amino Acid Family Metabolic Process Negative Regulation Of Ossification Response To Immobilization Stress Serotonin Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Indolalkylamine Biosynthetic Process Bone Remodeling Mammary Gland Alveolus Development	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Serotonin and melatonin biosynthesis NGF-stimulated transcription	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs		Sapropterin LX1031 Telotristat ethyl	Phenethyl Isothiocyanate
Diseases
GWAS		Glucose homeostasis traits ( 30576415) HDL cholesterol ( 30275531) White blood cell count ( 32888494)	Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)
Interacting Genes		6 interacting genes: APP GORASP2 PRKACA PSTPIP1 YWHAH YWHAZ	66 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36
Entrez ID		7166	7533
HPRD ID		01846	00215
Ensembl ID		ENSG00000129167	ENSG00000128245
Uniprot IDs		P17752	A0A024R1K7 Q04917 Q9H4N8
PDB IDs		1IN9 1MLW 3HF6 3HF8 3HFB 5J6D 5L01 5TPG	2C63 2C74
Enriched GO Terms of Interacting Partners?
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