PDE10A and CASP3

Data Source:
HPRD (in vitro)

		PDE10A	CASP3
Description		phosphodiesterase 10A	caspase 3
Image
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Death-inducing Signaling Complex Neuronal Cell Body Membrane Raft
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity CAMP Binding CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Protease Binding Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Death Receptor Binding Protein Binding Peptidase Activity Phospholipase A2 Activator Activity Protein-containing Complex Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CGMP-mediated Signaling CGMP Catabolic Process	Luteolysis Response To Hypoxia B Cell Homeostasis Apoptotic DNA Fragmentation Proteolysis Apoptotic Process Cellular Response To DNA Damage Stimulus Axonal Fasciculation Heart Development Sensory Perception Of Sound Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To UV Response To Glucose Response To X-ray Regulation Of Macroautophagy Protein Processing Cytokine-mediated Signaling Pathway Hippocampus Development Neuron Differentiation Keratinocyte Differentiation Erythrocyte Differentiation Platelet Formation Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Response To Tumor Necrosis Factor Response To Nicotine Hippo Signaling Wound Healing Response To Drug Response To Hydrogen Peroxide T Cell Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Neuron Apoptotic Process Cell Fate Commitment Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Activated T Cell Proliferation Response To Antibiotic Neurotrophin TRK Receptor Signaling Pathway Striated Muscle Cell Differentiation Response To Glucocorticoid Neuron Apoptotic Process Anterior Neural Tube Closure Leukocyte Apoptotic Process Cellular Response To Staurosporine Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Amyloid-beta Formation
Pathways		cGMP effects G alpha (s) signalling events	Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Apoptosis induced DNA fragmentation Degradation of the extracellular matrix Signaling by Hippo NADE modulates death signalling Stimulation of the cell death response by PAK-2p34 Caspase-mediated cleavage of cytoskeletal proteins Apoptotic cleavage of cell adhesion proteins Caspase activation via Dependence Receptors in the absence of ligand Caspase activation via Dependence Receptors in the absence of ligand Other interleukin signaling
Drugs		Caffeine Dipyridamole Papaverine 4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline 2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline Mardepodect 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE PQ-10 Tofisopam Triflusal Trapidil	Pamidronic acid Acetylsalicylic acid Minocycline 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid Emricasan Incadronic acid 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide Glycyrrhizic acid
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758) Body mass index ( 28552196) Body size at age 10 ( 32376654) Chronotype ( 30696823) Conduct disorder (symptom count) ( 20585324) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure ( 28135244 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 27182965) Inhibitory control ( 29251981) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Systolic blood pressure ( 27841878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335)	Blood protein levels ( 28240269) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Kawasaki disease ( 33106546)
Interacting Genes		3 interacting genes: CASP3 TOP1 WDR3	157 interacting genes: ACIN1 ADD1 AFP AIFM1 AKAP8 AKT1 APAF1 APP AR ARHGDIA ARHGDIB ARNT ATG4D ATN1 BCAP31 BCAR1 BCL2 BECN1 BID BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BLM BMX BRCA1 CAD CASP10 CASP2 CASP4 CASP6 CASP7 CASP8 CASP9 CAST CDC27 CDC42 CDH1 CDK11B CDKN1A CFLAR COPS6 CRYAB CTNNB1 CTTN DBNL DCC DCTN1 DEDD DFFA DSG3 EIF2AK2 EIF2S1 EIF3J EIF4B EIF4G2 FYN GATA1 GLRX GMNN GOLGA3 GORASP1 GRIPAP1 GSN GZMB HCLS1 HIP1 HMGB1 HNRNPU HSPD1 HSPE1 HTT IL16 IL18 KCNIP3 KRT18 LMNB1 LYN MAP4K1 MAPK8 MAPK8IP3 MAPK9 MAPT MCL1 MDC1 MDM2 MDM4 MEF2A MET MLH1 MYL3 NDUFS1 NEDD4 NFE2L2 NMT2 PAK2 PARG PARP1 PDE10A PDE5A PICALM PIP5K1A PKN1 PKN2 PLA2G4A PLA2G4B PPP3CA PRKCQ PRKCZ PRKDC PSEN1 PSEN2 PSIP1 PSME3 PTBP1 PTGES3 PTMA PXN RABEP1 RAC1 RAD51 RASA1 RB1 RFC1 RNF2 ROCK1 SARS2 SLK SNRNP70 SOCS5 SOHLH1 SP1 SPTAN1 SREBF2 SRF SRP72 STAT1 STK24 STK3 STK4 TFAP2A TGM2 THAP11 TNFSF10 TOP1 TRAF1 TRAF3 UBE4B USO1 VAV1 VIM WEE1 XIAP YWHAE YWHAG ZBTB16
Entrez ID		10846	836
HPRD ID		17828	02799
Ensembl ID		ENSG00000112541	ENSG00000164305
Uniprot IDs		A0A1B1UZQ1 A0A1B1UZR0 Q9Y233	P42574
PDB IDs		1LRB 2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 3WI2 3WS8 3WS9 3WYK 3WYL 3WYM 4AEL 4AJD 4AJF 4AJG 4AJM 4BBX 4DDL 4DFF 4FCB 4FCD 4HEU 4HF4 4LKQ 4LLJ 4LLK 4LLP 4LLX 4LM0 4LM1 4LM2 4LM3 4LM4 4MRW 4MRZ 4MS0 4MSA 4MSC 4MSE 4MSH 4MSN 4MUW 4MVH 4P0N 4P1R 4PHW 4TPM 4TPP 4WN1 4XY2 4YQH 4YS7 4ZO5 5AXP 5AXQ 5B4K 5B4L 5C1W 5C28 5C29 5C2A 5C2E 5C2H 5DH4 5DH5 5EDE 5EDG 5EDH 5EDI 5I2R 5K9R 5UWF 5XUI 5XUJ 5ZNL 6IJH 6IJI 6KDX 6KDZ 6KE0 6KO0 6KO1 6KZE 6MSA 6MSC	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4
Enriched GO Terms of Interacting Partners?
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