TNS1 and KLF10

Data Source:
BioGRID (two hybrid)

		TNS1	KLF10
Description		tensin 1	Kruppel like factor 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Focal Adhesion Cell Surface	Chromatin Nucleus
	Molecular Function	RNA Binding Actin Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Circadian Rhythm Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Bone Mineralization Somatic Stem Cell Population Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Peptide
Pathways
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma and hay fever ( 24388013) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery disease ( 29212778 33020668) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 20881960 25282103 25429064) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 29617998 29785010 30054594 29235454) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Mitral valve prolapse ( 26301497) Pulmonary function ( 20010834) Pulmonary function (smoking interaction) ( 23284291) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 30578418)	Chronic lymphocytic leukemia ( 23770605) IgA nephropathy ( 26028593) Neurofibrillary tangles ( 31497858) Urate levels ( 31578528)
Interacting Genes		15 interacting genes: AR CAPN2 EGFR ERBB2 ERBB3 ERBB4 FRS3 GAB1 KIT KLF10 MET OSGEP PPP1CC PTK2 YWHAZ	17 interacting genes: BOP1 CDK2 CDK6 CRIP2 FBXW7 KAT2B LENG1 PIGC RPL14 SF3B3 SIAH1 SIN3A SNHG29 SP1 TNS1 TULP3 ZNF512B
Entrez ID		7145	7071
HPRD ID		02512	03527
Ensembl ID		ENSG00000079308	ENSG00000155090
Uniprot IDs		A1L0S7 B2RU35 B7Z6H8 E9PF55 E9PGF5 Q0VG54 Q0VG55 Q59G71 Q86VB0 Q9HBL0	Q13118
PDB IDs			2EPA
Enriched GO Terms of Interacting Partners?
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