TNNT2 and TNNI1

Data Source:
BioGRID (two hybrid)

		TNNT2	TNNI1
Description		troponin T2, cardiac type	troponin I1, slow skeletal type
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex	Cytosol Troponin Complex
	Molecular Function	Actin Binding Protein Binding Tropomyosin Binding Troponin C Binding Troponin I Binding	Actin Binding Protein Binding Metal Ion Binding
	Biological Process	Muscle Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Skeletal Muscle Contraction Muscle Contraction Regulation Of Striated Muscle Contraction Muscle Filament Sliding Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS		Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196) Neurofibrillary tangles ( 25188341)
Interacting Genes		16 interacting genes: APP KDM1A MAP3K5 MLX MORF4L1 MORF4L2 MST1 NOTCH3 PPP2R5A PRKCA TNNC1 TNNI1 TNNI3 TNNT1 TPM1 TRIM69	46 interacting genes: ACTA1 ANKRD11 ARMC7 C2orf68 CABP2 CABP5 CCDC102B CCDC57 CCDC85B CDCA7L CEP19 CETN3 CTNNA3 DCAF11 EAF1 EFCAB2 EIF1AD EIF3B ENKD1 ESRRG KIFC3 L3MBTL2 MBD3 MCRS1 MDFI MNS1 MTUS2 PIH1D2 PIK3R3 PKD2L1 PNMA1 POLR1C PRKAB2 SAT1 SCNM1 SPANXN2 SYCE1L TNNC1 TNNT1 TNNT2 TPM3 TRIM41 TRIM55 TRIM63 USP20 ZNF76
Entrez ID		7139	7135
HPRD ID		01844	01842
Ensembl ID		ENSG00000118194	ENSG00000159173
Uniprot IDs		A0A0A0MRJ5 P45379 Q15607	P19237
PDB IDs		1J1D 1J1E 4Y99 6KN7 6KN8
Enriched GO Terms of Interacting Partners?
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