TNNT2 and TRIM69

Data Source:
BioGRID (two hybrid)

		TNNT2	TRIM69
Description		troponin T2, cardiac type	tripartite motif containing 69
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GO Annotations	Cellular Component	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex	Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Actin Binding Protein Binding Tropomyosin Binding Troponin C Binding Troponin I Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Muscle Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Protein Polyubiquitination Apoptotic Process Protein Ubiquitination
Pathways		Striated Muscle Contraction	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS		Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196) Neurofibrillary tangles ( 25188341)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		16 interacting genes: APP KDM1A MAP3K5 MLX MORF4L1 MORF4L2 MST1 NOTCH3 PPP2R5A PRKCA TNNC1 TNNI1 TNNI3 TNNT1 TPM1 TRIM69	53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483
Entrez ID		7139	140691
HPRD ID		01844	11518
Ensembl ID		ENSG00000118194	ENSG00000185880
Uniprot IDs		A0A0A0MRJ5 P45379 Q15607	H0YL66 Q86WT6
PDB IDs		1J1D 1J1E 4Y99 6KN7 6KN8	4NQJ 6YXE
Enriched GO Terms of Interacting Partners?
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