TNNI3 and PKD2L1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		TNNI3	PKD2L1
Description		troponin I3, cardiac type	polycystin 2 like 1, transient receptor potential cation channel
Image
GO Annotations	Cellular Component	Cytosol Troponin Complex Sarcomere Cardiac Myofibril Cardiac Troponin Complex	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Vesicle Calcium Channel Complex Intracellular Membrane-bounded Organelle Receptor Complex Ciliary Membrane Non-motile Cilium
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding	Calcium Activated Cation Channel Activity Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cation Transmembrane Transporter Activity Calcium-activated Potassium Channel Activity Sour Taste Receptor Activity Identical Protein Binding Muscle Alpha-actinin Binding Alpha-actinin Binding
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Cation Transport Smoothened Signaling Pathway Response To Water Sodium Ion Transmembrane Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		Striated Muscle Contraction Ion homeostasis
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Platelet count ( 32888494)	Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 30224653) Fatty acid desaturase activity (adipose tissue) ( 30453627) Glycerophospholipid levels ( 26068415) Heel bone mineral density ( 30598549 28869591) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Mean platelet volume ( 32888494 27863252) Monocyte count ( 32888494) Obesity-related traits ( 23251661) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Phospholipid levels (plasma) ( 22359512) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum metabolite levels ( 24625756) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Squamous cell lung carcinoma ( 28604730) Vaccenic acid (18:1n-7) levels ( 28298293)
Interacting Genes		19 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RASSF10 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	4 interacting genes: CLDN19 TNNI1 TNNI2 TNNI3
Entrez ID		7137	9033
HPRD ID		11769	16063
Ensembl ID		ENSG00000129991	ENSG00000107593
Uniprot IDs		P19429 Q6FGX2	Q1L4F0 Q9P0L9
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI	3TE3 4GIF 6DU8
Enriched GO Terms of Interacting Partners?
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