TNNI3 and RCAN3

Data Source:
BioGRID (protein complementation assay)
HPRD (two hybrid, in vitro)

		TNNI3	RCAN3
Description		troponin I3, cardiac type	RCAN family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex Sarcomere Cardiac Myofibril Cardiac Troponin Complex	Nucleus Cytoplasm
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding	RNA Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Phosphatase Binding Troponin I Binding
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Anatomical Structure Morphogenesis Calcium-mediated Signaling Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Striated Muscle Contraction Ion homeostasis
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Platelet count ( 32888494)	Male-pattern baldness ( 28196072)
Interacting Genes		19 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RASSF10 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	5 interacting genes: EPS8 TNNI3 TRIM23 UNC119 ZDHHC17
Entrez ID		7137	11123
HPRD ID		11769	05792
Ensembl ID		ENSG00000129991	ENSG00000117602
Uniprot IDs		P19429 Q6FGX2	A0A024RAH2 Q9UKA8
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI
Enriched GO Terms of Interacting Partners?
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