TNFAIP6 and ACAN

Data Source:
HPRD (in vitro)

		TNFAIP6	ACAN
Description		TNF alpha induced protein 6	aggrecan
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Hyaluronic Acid Binding	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding
	Biological Process	Inflammatory Response Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Migration Ovulation Neutrophil Degranulation Negative Regulation Of Inflammatory Response	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Keratan Sulfate Catabolic Process
Pathways		Neutrophil degranulation	Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		Donepezil Acetylsalicylic acid Hyaluronic acid	Ilomastat
Diseases			Spondyloepiphyseal dysplasia, Kimberley type Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
GWAS		Blood protein levels ( 30072576 29875488 28240269) Lung cancer ( 23143601)	Age-related hearing impairment ( 27764096) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		3 interacting genes: ACAN THBS1 UBC	18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR
Entrez ID		7130	176
HPRD ID		02680	01123
Ensembl ID		ENSG00000123610	ENSG00000157766
Uniprot IDs		P98066	P16112
PDB IDs		1O7B 1O7C 2N40 2PF5 2WNO	4MD4
Enriched GO Terms of Interacting Partners?
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