TNFAIP1 and RHOB

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TNFAIP1	RHOB
Description		TNF alpha induced protein 1	ras homolog family member B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cul3-RING Ubiquitin Ligase Complex	Nucleus Early Endosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Cytoplasmic Vesicle Late Endosome Membrane Cleavage Furrow Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Small GTPase Binding Identical Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	Apoptotic Process Immune Response Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Endosome To Lysosome Transport Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Cell Migration Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation
Pathways			GPVI-mediated activation cascade Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs			Botulinum toxin type A
Diseases
GWAS		Blood protein levels ( 29875488) Low density lipoprotein cholesterol levels ( 29403010) Osteoprotegerin levels ( 25080503)	Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		31 interacting genes: ARMC7 ARNT CAPN7 CARD9 CDC37 CSNK2B DAPP1 EPHA2 EPM2AIP1 EXOSC5 HAT1 HEXIM2 KCTD10 KCTD13 KDM1A LNX1 NTAQ1 NXF1 POLR1C PRKAG1 PSMA1 RHOA RHOB RIN3 SMARCB1 STK16 SUV39H1 SVIL TRIM54 ZDHHC17 ZMYND19	12 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PPP2CA RHPN2 SMURF1 TNFAIP1
Entrez ID		7126	388
HPRD ID		01856	01321
Ensembl ID		ENSG00000109079	ENSG00000143878
Uniprot IDs		Q13829	P62745
PDB IDs			2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?
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