TMOD1 and FBXL17

Data Source:
BioGRID (two hybrid)

		TMOD1	FBXL17
Description		tropomodulin 1	F-box and leucine rich repeat protein 17
Image
GO Annotations	Cellular Component	Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament COP9 Signalosome Membrane Myofibril Sarcomere Cortical Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Actin Binding Tropomyosin Binding Actin Filament Binding	Protein Binding
	Biological Process	Muscle Contraction Actin Filament Organization Adult Locomotory Behavior Muscle Filament Sliding Myofibril Assembly Pointed-end Actin Filament Capping Lens Fiber Cell Development	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Nervous System Development Regulation Of Smoothened Signaling Pathway Neural Crest Cell Differentiation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS		Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Intracranial aneurysm ( 30823506) Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937) Zinc levels ( 26025379)	Adult body size ( 32376654) Bipolar disorder (body mass index interaction) ( 24322204) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Carotid intima media thickness x smoking interaction ( 32117412) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31015462) Experiencing mood swings ( 29500382) Eye color ( 23118974) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29235454) Irritable mood ( 29500382) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neurociticism ( 29500382) Number of children ever born ( 27798627) Pulse pressure ( 30224653) Response to amphetamines ( 22952603) Smoking status (ever vs never smokers) ( 30643258) Weight ( 28552196)
Interacting Genes		16 interacting genes: APC BUB1 CDH1 CDKN2A DCC DLC1 FBXL17 FBXW7 MLH3 NEB ODC1 PIK3CA PRKAA2 TLR2 TMSB10 TPM3	42 interacting genes: ACSBG2 AK9 C21orf91 CCSER1 CFAP58 CLPX COG2 ETFA FILIP1L HADH IDO1 IFT46 KBTBD8 KLHL12 KLHL7 MED14 METAP2 OLR1 PCCB PHF7 PPP3CB PRMT1 PSME4 PXYLP1 RLF SCG5 SCPEP1 SRBD1 SUFU TASP1 TGFBI TMEM126A TMOD1 TPP2 UAP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 USP25 ZMYM2 ZNF350
Entrez ID		7111	64839
HPRD ID		01838	10950
Ensembl ID		ENSG00000136842	ENSG00000145743
Uniprot IDs		P28289	Q9UF56
PDB IDs		4PKG 4PKH 4PKI 4Z8G 4Z94	6W66 6WCQ
Enriched GO Terms of Interacting Partners?
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