TLL1 and CHRD

Data Source:
HPRD (in vitro)

		TLL1	CHRD
Description		tolloid like 1	chordin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding	Protein Binding Cytokine Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Cell Differentiation	Skeletal System Development Positive Regulation Of Mesenchymal Cell Proliferation BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion
Pathways		Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index ( 28552196) Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia ( 29266176) Cerebrospinal fluid clusterin levels ( 26545630) Glomerular filtration rate in chronic kidney disease ( 26420894) Hepatocellular carcinoma in post hepatitis C eradication by interferon therapy ( 28163062) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29785010) Multiple sclerosis ( 23412934) Obesity-related traits ( 23251661) Post-traumatic stress disorder ( 23726511) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Serum bilirubin levels in metabolic syndrome ( 30621171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196) Western dietary pattern ( 28644415)	Diisocyanate-induced asthma ( 25918132) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet count ( 32888494 20139978) Plateletcrit ( 32888494 27863252)
Interacting Genes		2 interacting genes: APP CHRD	57 interacting genes: ADAMTSL4 ATN1 BMP1 BMP2 CATSPER1 CD36 CHRDL2 CYSRT1 F2R GATA1 HOXA1 HRG INCA1 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP19-2 KRTAP19-5 KRTAP22-1 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 LCE1C LCE1F LCE5A LIN7A MEOX2 NBPF19 NOTCH2NLA NR0B2 NR4A3 OTX1 PLSCR1 POU4F2 RGS17 SLC15A2 SMAD3 SPRY1 SPRY2 SPRY3 TLL1 TRIM42 TSPAN4 TWSG1
Entrez ID		7092	8646
HPRD ID		07074	04592
Ensembl ID		ENSG00000038295	ENSG00000090539
Uniprot IDs		B7ZLW3 O43897	E7ESX1 Q8N2W7 Q9H2X0
PDB IDs		3EDI
Enriched GO Terms of Interacting Partners?
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