TIAM1 and PARD3

Data Source:
HPRD (in vitro, in vivo)

		TIAM1	PARD3
Description		TIAM Rac1 associated GEF 1	par-3 family cell polarity regulator
Image
GO Annotations	Cellular Component	Nucleus Cytosol Microtubule Plasma Membrane Cell-cell Junction Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Neuronal Cell Body Dendritic Spine Cell-cell Contact Zone Axonal Growth Cone Main Axon Synapse Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Apical Plasma Membrane Cell Junction Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Apical Junction Complex Axonal Growth Cone
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Lipid Binding Kinase Binding Receptor Tyrosine Kinase Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Cardiac Muscle Hypertrophy Apoptotic Process Cell-matrix Adhesion G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Protein Binding Cellular Protein-containing Complex Assembly Response To Cocaine Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Activation Of GTPase Activity NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Schwann Cell Chemotaxis Regulation Of Dopaminergic Neuron Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Neuron Projection Extension Regulation Of Non-canonical Wnt Signaling Pathway	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Cycle Cell Adhesion Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Centrosome Localization Regulation Of Cellular Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways		NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events Activated NTRK2 signals through CDK5	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Renal sinus fat ( 22044751) Waist circumference ( 28552196)	Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)
Interacting Genes		33 interacting genes: ABCA1 ANK1 BTRC CAMK2G CD44 CDC42 CSNK1A1 EFNB1 EPHA2 FNDC3B HRAS MAPK8IP1 MAPK8IP2 MYC NME1 OSBPL1A PARD3 PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAC1 RHOA SRC SRSF5 SYCP1 UBC YWHAG ZKSCAN4	29 interacting genes: CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN YWHAB YWHAG YWHAH YWHAZ
Entrez ID		7074	56288
HPRD ID		02820	05994
Ensembl ID		ENSG00000156299	ENSG00000148498
Uniprot IDs		A0A2X0TW27 Q13009	Q8TEW0
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR	2KOM
Enriched GO Terms of Interacting Partners?
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