PARD3 and INSC

Data Source:
HPRD (in vivo)

		PARD3	INSC
Description		par-3 family cell polarity regulator	INSC spindle orientation adaptor protein
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Apical Plasma Membrane Cell Junction Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Apical Junction Complex Axonal Growth Cone	Plasma Membrane Cell Cortex Protein-containing Complex Apical Cortex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Identical Protein Binding	Protein Binding Cytoskeletal Anchor Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity
	Biological Process	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Cycle Cell Adhesion Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Centrosome Localization Regulation Of Cellular Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity	Establishment Of Mitotic Spindle Orientation Nervous System Development Asymmetric Cell Division Regulation Of Asymmetric Cell Division Cell Differentiation Regulation Of Protein Stability Apical Protein Localization
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)	Expressive vocabulary in infants ( 25226531) Heel bone mineral density ( 30598549 28869591) Menarche (age at onset) ( 23667675) Obesity-related traits ( 23251661)
Interacting Genes		29 interacting genes: CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN YWHAB YWHAG YWHAH YWHAZ	17 interacting genes: CCDC187 GEM GPANK1 GPSM1 GPSM2 LHX3 LNX1 PARD3 PARD3B PRR35 RUSC1 SMARCD1 SORBS3 TEKT3 TTC23 USP54 ZNF587
Entrez ID		56288	387755
HPRD ID		05994	18803
Ensembl ID		ENSG00000148498	ENSG00000188487
Uniprot IDs		Q8TEW0	Q1MX18
PDB IDs		2KOM	3SF4
Enriched GO Terms of Interacting Partners?
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