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JAK1 and SOCS3
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
JAK1
SOCS3
Description
Janus kinase 1
suppressor of cytokine signaling 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endosome
Cytosol
Cytoskeleton
Focal Adhesion
Membrane
Cytosol
Phosphatidylinositol 3-kinase Complex
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Growth Hormone Receptor Binding
Protein Binding
ATP Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
CCR5 Chemokine Receptor Binding
Metal Ion Binding
Phosphotyrosine Residue Binding
Protein Kinase Inhibitor Activity
Protein Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Biological Process
MAPK Cascade
Protein Phosphorylation
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Homotypic Cell-cell Adhesion
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Response To Antibiotic
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Protein Localization To Cell-cell Junction
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Protein Kinase Activity
Receptor Signaling Pathway Via JAK-STAT
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Regulation Of Growth
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Post-translational Protein Modification
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Phosphatidylinositol Phosphorylation
Negative Regulation Of Inflammatory Response
Regulation Of Interferon-gamma-mediated Signaling Pathway
Branching Involved In Labyrinthine Layer Morphogenesis
Placenta Blood Vessel Development
Trophoblast Giant Cell Differentiation
Interleukin-6-mediated Signaling Pathway
Cellular Response To Leukemia Inhibitory Factor
Pathways
Interleukin-6 signaling
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
ISG15 antiviral mechanism
Interleukin-7 signaling
Interleukin-7 signaling
Other interleukin signaling
RAF/MAP kinase cascade
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-27 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling
Regulation of IFNA signaling
Potential therapeutics for SARS
Interleukin-6 signaling
Signaling by Leptin
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
PTK6 Activates STAT3
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Neddylation
Interferon alpha/beta signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Myricetin
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
Ruxolitinib
Tofacitinib
Baricitinib
Fostamatinib
Fedratinib
Filgotinib
Upadacitinib
Pralsetinib
Diseases
GWAS
Autoimmune thyroid disease (
32581359
)
Core binding factor acute myeloid leukemia (
27903959
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Medication use (thyroid preparations) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of granulocytes (
27863252
)
Plasma anti-thyroglobulin levels (
29678681
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Asthma (
32296059
)
Blood trace element (Se levels) (
23720494
)
Creatine kinase levels (
29403010
)
Interacting Genes
72 interacting genes:
ABL1
AGTR1
BRCA1
BTK
CCR1
CCR5
CSF2RB
CSF3R
CXCR4
EIF2AK2
ELP2
ERBB2
FER
FES
GAB1
GHR
GRB2
H3-4
IFNAR2
IFNGR1
IGF1R
IL10RA
IL21R
IL2RB
IL2RG
IL3RA
IL4R
IL5RA
IL6ST
IL7R
IL9R
INPP5D
INSR
IRS1
IRS2
JAK3
JAKMIP1
MDK
OSMR
PDGFRA
PDGFRB
PIK3R1
PLA2G4A
PLAUR
PLCG2
PRKCZ
PRMT5
PTK2B
PTPN11
PTPN2
PTPN6
PTPRC
RACK1
RAF1
SH2B2
SHB
SOCS1
SOCS3
STAM
STAM2
STAT1
STAT2
STAT3
STAT5A
STAT6
SYK
TEC
TNFRSF1A
TOP1
TSHR
TYK2
USP6
63 interacting genes:
ABL1
ACADVL
APP
AR
BCL10
BIK
BLK
CSF1R
CSF3R
CSNK1E
CUEDC2
CXCR4
EGFR
ELOB
ELOC
EPOR
ERBB2
ERBB3
ERBB4
GAB1
GFRA1
GHR
HIVEP1
IGF1R
IL12RB2
IL2RB
IL6ST
INSR
IRF7
IRS1
IRS2
JAK1
JAK2
JAK3
KIAA1958
KIT
LEPR
MAP1S
MAPK11
MAPK6
MET
NME4
PDPK1
PIN1
PPP3CB
PRLR
PTK2
PTPN11
RASA1
RBMX
RNF31
RNF7
RPL7A
SH2D2A
SOCS2
TES
TFDP1
TFR2
TRDN
TXK
TXNDC11
YES1
YWHAQ
Entrez ID
3716
9021
HPRD ID
00992
05006
Ensembl ID
ENSG00000162434
ENSG00000184557
Uniprot IDs
P23458
Q6P669
O14543
Q6FI39
PDB IDs
3EYG
3EYH
4E4L
4E4N
4E5W
4EHZ
4EI4
4FK6
4GS0
4I5C
4IVB
4IVC
4IVD
4K6Z
4K77
4L00
4L01
5E1E
5HX8
5IXD
5IXI
5KHW
5KHX
5L04
5WO4
6AAH
6BBU
6C7Y
6DBN
6ELR
6GGH
6HZU
6N77
6N78
6N79
6N7A
6N7B
6N7C
6N7D
6RSB
6RSC
6RSD
6RSE
6RSH
6SM8
6SMB
6TPE
6TPF
6W8L
Enriched GO Terms of Interacting Partners
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