TBX6 and TBX15

Data Source:
BioGRID (two hybrid)

		TBX6	TBX15
Description		T-box transcription factor 6	T-box transcription factor 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin RNA Polymerase II Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Heart Looping Cardiac Chamber Development Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Mesoderm Development Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Negative Regulation Of Neuron Projection Development Negative Regulation Of Neuron Maturation Signal Transduction Involved In Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis
Pathways
Drugs
Diseases			Cousin syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Eosinophil counts ( 32888494 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244) Red blood cell count ( 29403010 32888494 27863252) Reticulocyte count ( 32888494) Schizophrenia ( 25056061 29483656) Sum eosinophil basophil counts ( 27863252)	Adult body size ( 32376654) Antitragus size ( 26105758) Birth weight ( 31043758) Body mass index ( 28892062 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) Chin dimples ( 27182965) Congenital heart malformation ( 23708190) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Ear morphology ( 26105758) Excessive hairiness ( 29895819) Facial morphology ( 31763980) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Folding of antihelix ( 26105758) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lung function (FVC) ( 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Male-pattern baldness ( 27182965 28196072) Physiological traits ( 31902109) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 28552196) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412 28448500)
Interacting Genes		39 interacting genes: C10orf55 C19orf54 C1orf94 CRX CYSRT1 DAZAP2 HSFY1 HSFY2 INTS11 KLHDC7B KRTAP11-1 KRTAP13-1 KRTAP6-2 KRTAP6-3 MAGED1 MEOX2 METTL27 MGAT5B PLA2G10 POU2AF1 POU6F2 PRMT1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RBPMS TBX15 TBX19 TCP11L1 TENT5B TLE5 TOX4 TSC1 USP54 YPEL3 ZNF34	12 interacting genes: ATXN1 DOK6 DTX2 HOXA1 MYOZ3 NTAQ1 POLE2 RHOBTB3 TBX6 TEKT5 VENTX VGLL3
Entrez ID		6911	6913
HPRD ID		03888	16035
Ensembl ID		ENSG00000149922	ENSG00000092607
Uniprot IDs		O95947	Q8N8P2 Q96SF7
PDB IDs
Enriched GO Terms of Interacting Partners?
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