TAPBP and TAP1

Data Source:
HPRD (in vivo, in vitro)

		TAPBP	TAP1
Description		TAP binding protein	transporter 1, ATP binding cassette subfamily B member
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Centriolar Satellite MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	Protein Binding ABC-type Peptide Antigen Transporter Activity MHC Class I Protein Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding Unfolded Protein Binding TAP Complex Binding	Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity ADP Binding TAP1 Binding TAP2 Binding Peptide Transmembrane Transporter Activity
	Biological Process	MHC Class Ib Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Immune Response Regulation Of Gene Expression Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Antigen Stabilization Regulation Of Protein Complex Stability Protein-containing Complex Assembly Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Protein Transport Peptide Transport Viral Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Transmembrane Transport Anion Transmembrane Transport Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Pathways		ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases		Bare lymphocyte syndrome (BLS) type1	Bare lymphocyte syndrome (BLS) type1 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576 29875488)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) IgA nephropathy ( 25305756) Metabolite levels ( 23823483) Nephropathy ( 21399633)
Interacting Genes		9 interacting genes: CALR COPB1 COPG1 COPG2 HLA-A HLA-C TAP1 TAP2 UBC	27 interacting genes: AQP6 CHRM3 CREB3 ERGIC3 ERVFRD-1 ESR1 GEMIN4 GPR152 HLA-F HLA-G KRTAP4-12 LCE2C LMNA MDFI MUL1 PDIA3 PSMB5 PSMB8 RNF19B SLC10A1 SLC10A6 SLC35C2 SSMEM1 TAP2 TAPBP TDP2 TMEM14B
Entrez ID		6892	6890
HPRD ID		09061	01359
Ensembl ID		ENSG00000231925	ENSG00000168394
Uniprot IDs		A0A024RCT1 A0A0A0MSV9 A0A0A0MT98 O15533	A0A0S2Z5A6 B7Z7P4 Q03518 X5CKB3
PDB IDs		3F8U 6ENY	1JJ7 5U1D
Enriched GO Terms of Interacting Partners?
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