TACR1 and CCDC167

Data Source:
BioGRID (two hybrid)

		TACR1	CCDC167
Description		tachykinin receptor 1	coiled-coil domain containing 167
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Sperm Flagellum Sperm Head Sperm Midpiece	Integral Component Of Membrane
	Molecular Function	Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity	Protein Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Detection Of Abiotic Stimulus Response To Pain Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Tramadol Aprepitant Ketamine Vapreotide AV608 GW 597599 CP-122721 R673 SR 140333 Casopitant Netupitant Rolapitant Vestipitant Vofopitant Fosnetupitant
Diseases
GWAS		Brain connectivity ( 23471985) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Gout ( 32238385) Nonunion in individuals with fractures ( 30680360) Pursuit maintenance gain ( 29064472) Seborrheic dermatitis ( 29203360) Sexual dimorphism in anthropometric traits ( 23754948) Weight ( 28552196)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		7 interacting genes: CCDC167 GPRASP1 GRK5 TAC1 TAC3 TAC4 TMEM147	42 interacting genes: APPBP2 AQP2 AQP6 AQP9 ARL13B CD79A CLDN5 CX3CR1 EBP ELOVL4 ERGIC3 FAM174A FAM210B FFAR2 GJA8 GLP1R GOLT1A GPR152 GPR42 HSD17B13 MS4A3 MTNR1A MUC1 NIPA1 OPRM1 RETREG3 SERINC2 SLC10A6 SLC18A3 SLC35C2 SLC7A14 SYT2 TACR1 TLCD4 TM4SF19 TMEM179B TMEM237 TMEM51 TMEM80 TMEM86B TMX2 VKORC1
Entrez ID		6869	154467
HPRD ID		01208	18561
Ensembl ID		ENSG00000115353	ENSG00000198937
Uniprot IDs		P25103	Q9P0B6
PDB IDs		2KS9 2KSA 2KSB 6E59 6HLL 6HLO 6HLP
Enriched GO Terms of Interacting Partners?
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