CCDC167 and CX3CR1

Data Source:
BioGRID (two hybrid)

		CCDC167	CX3CR1
Description		coiled-coil domain containing 167	C-X3-C motif chemokine receptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Neuronal Cell Body Membrane Neuron Projection Perinuclear Region Of Cytoplasm Dendritic Tree
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity C-C Chemokine Receptor Activity C-X3-C Chemokine Receptor Activity C-C Chemokine Binding C-X3-C Chemokine Binding
	Biological Process		Positive Regulation Of Neuroblast Proliferation Response To Ischemia Chemotaxis Immune Response Cellular Defense Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Memory Response To Wounding Viral Process Calcium-mediated Signaling Central Nervous System Maturation Negative Regulation Of Cell Migration Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-1 Beta Production Social Behavior Autocrine Signaling Innate Immune Response Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Synaptic Plasticity Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Synapse Maturation Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Transforming Growth Factor Beta Stimulus Synapse Pruning Negative Regulation Of Hippocampal Neuron Apoptotic Process Multiple Spine Synapse Organization, Single Dendrite Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of I-kappaB Phosphorylation Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Migration Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Acne (severe) ( 24927181) Restless legs syndrome ( 29029846) Smoking status (ever vs never smokers) ( 30643258)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autoimmune thyroid disease ( 32581359) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		42 interacting genes: APPBP2 AQP2 AQP6 AQP9 ARL13B CD79A CLDN5 CX3CR1 EBP ELOVL4 ERGIC3 FAM174A FAM210B FFAR2 GJA8 GLP1R GOLT1A GPR152 GPR42 HSD17B13 MS4A3 MTNR1A MUC1 NIPA1 OPRM1 RETREG3 SERINC2 SLC10A6 SLC18A3 SLC35C2 SLC7A14 SYT2 TACR1 TLCD4 TM4SF19 TMEM179B TMEM237 TMEM51 TMEM80 TMEM86B TMX2 VKORC1	2 interacting genes: CCDC167 CX3CL1
Entrez ID		154467	1524
HPRD ID		18561	03277
Ensembl ID		ENSG00000198937	ENSG00000168329
Uniprot IDs		Q9P0B6	P49238
PDB IDs
Enriched GO Terms of Interacting Partners?
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