SYT5 and MEGF8

Data Source:
BioGRID (proximity labelling technology)

		SYT5	MEGF8
Description		synaptotagmin 5	multiple EGF like domains 8
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Axon Synaptic Vesicle Membrane Dense Core Granule Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Exocytic Vesicle Integral Component Of Neuronal Dense Core Vesicle Membrane Proximal Neuron Projection	Nucleus Integral Component Of Membrane Extracellular Exosome
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Syntaxin Binding Clathrin Binding Protein Heterodimerization Activity	Calcium Ion Binding Protein Binding
	Biological Process	Chemical Synaptic Transmission Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Endocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Cellular Response To Calcium Ion	Embryonic Heart Tube Morphogenesis Animal Organ Morphogenesis Tissue Development Regulation Of Gene Expression Embryonic Limb Morphogenesis BMP Signaling Pathway Limb Morphogenesis Cell Migration Involved In Gastrulation Negative Regulation Of Smoothened Signaling Pathway Embryonic Skeletal System Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Epiboly Involved In Gastrulation With Mouth Forming Second Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Coronary Vasculature Development Determination Of Heart Left/right Asymmetry Determination Of Digestive Tract Left/right Asymmetry Craniofacial Suture Morphogenesis Fasciculation Of Sensory Neuron Axon
Pathways		Regulation of insulin secretion
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		6 interacting genes: DNAJC5 HTR6 NRXN1 POLR2E RAB1A SYT3	3 interacting genes: ATN1 CACNA1A GFI1B
Entrez ID		6861	1954
HPRD ID		02870	10370
Ensembl ID		ENSG00000129990	ENSG00000105429
Uniprot IDs		A0A024R4N8 O00445 Q4FD32	Q7Z7M0
PDB IDs		5H4Y 5H4Z
Enriched GO Terms of Interacting Partners?
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