SURF1 and PTGES3

Data Source:
BioGRID (two hybrid)

		SURF1	PTGES3
Description		SURF1 cytochrome c oxidase assembly factor	prostaglandin E synthase 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Respirasome Integral Component Of Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytosol Protein-containing Complex Chaperone Complex
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding	Telomerase Activity Protein Binding Prostaglandin-E Synthase Activity Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding
	Biological Process	Oxidative Phosphorylation Respiratory Chain Complex IV Assembly Aerobic Respiration Electron Transport Chain Mitochondrial Cytochrome C Oxidase Assembly Proton Transmembrane Transport	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Xenobiotic Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Cyclooxygenase Pathway Positive Regulation Of Phosphorylation Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Chaperone-mediated Protein Complex Assembly Positive Regulation Of Telomerase Activity Regulation Of Cellular Response To Heat Telomerase Holoenzyme Complex Assembly
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS
Drugs			Acetaminophen Grn163l Copper
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Blood protein levels ( 28240269) Heart failure ( 31919418) Malaria ( 31844061)	Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)
Interacting Genes		1 interacting genes: PTGES3	29 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPB1 NR3C1 NR3C2 STIP1 SURF1 TERT THRA
Entrez ID		6834	10728
HPRD ID		01711	06138
Ensembl ID		ENSG00000148290	ENSG00000110958
Uniprot IDs		A0A087WYS9 E5KRX5 Q15526	A0A024RB32 A0A087WYT3 B3KUY2 Q15185
PDB IDs			1EJF 1LG0
Enriched GO Terms of Interacting Partners?
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