PTGES3 and SURF1

Data Source:
BioGRID (two hybrid)

		PTGES3	SURF1
Description		prostaglandin E synthase 3	SURF1 cytochrome c oxidase assembly factor
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytosol Protein-containing Complex Chaperone Complex	Mitochondrial Respirasome Integral Component Of Membrane
	Molecular Function	Telomerase Activity Protein Binding Prostaglandin-E Synthase Activity Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding	Cytochrome-c Oxidase Activity Protein Binding
	Biological Process	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Xenobiotic Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Cyclooxygenase Pathway Positive Regulation Of Phosphorylation Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Chaperone-mediated Protein Complex Assembly Positive Regulation Of Telomerase Activity Regulation Of Cellular Response To Heat Telomerase Holoenzyme Complex Assembly	Oxidative Phosphorylation Respiratory Chain Complex IV Assembly Aerobic Respiration Electron Transport Chain Mitochondrial Cytochrome C Oxidase Assembly Proton Transmembrane Transport
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS	TP53 Regulates Metabolic Genes Respiratory electron transport
Drugs		Acetaminophen Grn163l Copper
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)	Blood protein levels ( 28240269) Heart failure ( 31919418) Malaria ( 31844061)
Interacting Genes		29 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPB1 NR3C1 NR3C2 STIP1 SURF1 TERT THRA	1 interacting genes: PTGES3
Entrez ID		10728	6834
HPRD ID		06138	01711
Ensembl ID		ENSG00000110958	ENSG00000148290
Uniprot IDs		A0A024RB32 A0A087WYT3 B3KUY2 Q15185	A0A087WYS9 E5KRX5 Q15526
PDB IDs		1EJF 1LG0
Enriched GO Terms of Interacting Partners?
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