STRN and PDCD10

Data Source:
BioGRID (two hybrid)

		STRN	PDCD10
Description		striatin	programmed cell death 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Bicellular Tight Junction Postsynaptic Density Membrane Dendrite Neuronal Cell Body Dendritic Spine Postsynaptic Membrane FAR/SIN/STRIPAK Complex	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Binding Calmodulin Binding Estrogen Receptor Binding Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding	Protein Binding Protein Kinase Binding Protein Homodimerization Activity Protein N-terminus Binding
	Biological Process	Locomotory Behavior Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Dendrite Development Bicellular Tight Junction Assembly	Angiogenesis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Rho Protein Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAP Kinase Activity Wound Healing, Spreading Of Cells Positive Regulation Of Notch Signaling Pathway Protein Stabilization Establishment Of Golgi Localization Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Golgi Reassembly Positive Regulation Of Intracellular Protein Transport Regulation Of Golgi Organization Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Leukemia Inhibitory Factor
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Extra-nuclear estrogen signaling Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs
Diseases			Cerebral cavernous malformation
GWAS		Alanine transaminase levels ( 29403010) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) PR interval ( 32439900) QRS duration ( 27577874 27659466) Red cell distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549 32154731)	Fast beta electroencephalogram ( 28070124) Platelet count ( 32888494)
Interacting Genes		12 interacting genes: ATF7IP CALM1 CAV1 ESR1 GNAI1 LNX1 PDCD10 PPP2CA PPP2R1A PPP2R1B RINT1 TFIP11	12 interacting genes: C4orf19 CHMP5 FAM118B FARSA FRYL MINAR1 PLEKHS1 PROSER2 STK24 STK25 STK26 STRN
Entrez ID		6801	11235
HPRD ID		18124	10141
Ensembl ID		ENSG00000115808	ENSG00000114209
Uniprot IDs		O43815	C9J363 Q9BUL8
PDB IDs			3AJM 3L8I 3L8J 3RQE 3RQF 3RQG 3W8H 3W8I 4GEH 4TVQ
Enriched GO Terms of Interacting Partners?
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