STK4 and MBP

Data Source:
HPRD (in vitro)

		STK4	MBP
Description		serine/threonine kinase 4	myelin basic protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex	Nucleus Plasma Membrane Cell Surface Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protease Binding Protein Binding Calmodulin Binding Structural Constituent Of Myelin Sheath
	Biological Process	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Keratinocyte Differentiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Protein Stabilization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Signaling by Hippo	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Mean platelet volume ( 32888494) Platelet count ( 32888494)	Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)
Interacting Genes		23 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX DDIT4L H2BC21 IL2RG KEAP1 LATS1 MARK2 MBP NEDD4 PICK1 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 STK3 THAP12 TP53	81 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1
Entrez ID		6789	4155
HPRD ID		05395	01158
Ensembl ID		ENSG00000101109	ENSG00000197971
Uniprot IDs		Q13043	A0A024R384 P02686
PDB IDs		2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT	1BX2 1FV1 1HQR 1K2D 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?
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