STIM1 and RRM1

Data Source:
BioGRID (two hybrid)

		STIM1	RRM1
Description		stromal interaction molecule 1	ribonucleotide reductase catalytic subunit M1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Microtubule Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Plasma Membrane Raft	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body
	Molecular Function	Protease Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Microtubule Plus-end Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	Store-operated Calcium Entry Detection Of Calcium Ion Cellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Angiogenesis Regulation Of Calcium Ion Transport Enamel Mineralization Regulation Of Cardiac Conduction Regulation Of Store-operated Calcium Entry	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye
Pathways		Elevation of cytosolic Ca2+ levels Ion homeostasis Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Interconversion of nucleotide di- and triphosphates
Drugs			Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Calcium levels ( 29403010) Hemoglobin ( 32888494) Malaria ( 31844061) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 32888494 27863252)	Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		5 interacting genes: IFNGR1 INSIG2 RABAC1 SLC7A1 STIM2	10 interacting genes: BMI1 CDC42 LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655
Entrez ID		6786	6240
HPRD ID		05803	01588
Ensembl ID		ENSG00000167323	ENSG00000167325
Uniprot IDs		G0XQ39 Q13586	B4DXD1 B4E0I8 E9PL69 P23921
PDB IDs		2K60 2MAJ 2MAK 3TEQ 4O9B 6YEL	2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L
Enriched GO Terms of Interacting Partners?
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