STIM2 and STIM1

Data Source:
HPRD (in vivo, in vitro)

		STIM2	STIM1
Description		stromal interaction molecule 2	stromal interaction molecule 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Microtubule Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Plasma Membrane Raft
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Store-operated Calcium Channel Activity	Protease Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Microtubule Plus-end Binding
	Biological Process	Store-operated Calcium Entry Cellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport	Store-operated Calcium Entry Detection Of Calcium Ion Cellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Angiogenesis Regulation Of Calcium Ion Transport Enamel Mineralization Regulation Of Cardiac Conduction Regulation Of Store-operated Calcium Entry
Pathways			Elevation of cytosolic Ca2+ levels Ion homeostasis Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) General risk tolerance (MTAG) ( 30643258) Hirschsprung disease ( 25310821) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Refractive astigmatism ( 25367360) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus grey matter volume ( 25335168)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Calcium levels ( 29403010) Hemoglobin ( 32888494) Malaria ( 31844061) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 32888494 27863252)
Interacting Genes		3 interacting genes: CALM1 PRPF40A STIM1	5 interacting genes: IFNGR1 INSIG2 RABAC1 SLC7A1 STIM2
Entrez ID		57620	6786
HPRD ID		11609	05803
Ensembl ID		ENSG00000109689	ENSG00000167323
Uniprot IDs		B3KUB5 Q9P246	G0XQ39 Q13586
PDB IDs		2L5Y	2K60 2MAJ 2MAK 3TEQ 4O9B 6YEL
Enriched GO Terms of Interacting Partners?
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