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STAT6 and IFNG
Data Source:
BioGRID
(pull down)
STAT6
IFNG
Description
signal transducer and activator of transcription 6
interferon gamma
Image
GO Annotations
Cellular Component
Chromatin
Nucleoplasm
Cytosol
Extracellular Region
Extracellular Space
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Protein Phosphatase Binding
Identical Protein Binding
Cytokine Activity
Interferon-gamma Receptor Binding
Protein Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Receptor Signaling Pathway Via JAK-STAT
Cytokine-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Interleukin-4-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Response To Peptide Hormone
Positive Regulation Of Transcription By RNA Polymerase II
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Transcription By RNA Polymerase II
Microglial Cell Activation
Positive Regulation Of Cytokine Production
Positive Regulation Of Protein Phosphorylation
Adaptive Immune Response
Macrophage Activation Involved In Immune Response
Apoptotic Process
Humoral Immune Response
Cell Cycle Arrest
Cell Surface Receptor Signaling Pathway
Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Response To Virus
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Regulation Of Protein ADP-ribosylation
Macrophage Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Interleukin-17 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response
Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Interleukin-12-mediated Signaling Pathway
Regulation Of Growth
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Glycolytic Process
Negative Regulation Of Transcription, DNA-templated
Astrocyte Activation
Negative Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Phagocytosis
Positive Regulation Of Neurogenesis
Regulation Of Insulin Secretion
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Positive Regulation Of Nitrogen Compound Metabolic Process
Defense Response To Virus
Positive Regulation Of Killing Of Cells Of Other Organism
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of Fructose 1,6-bisphosphate 1-phosphatase Activity
Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process
Positive Regulation Of Vitamin D Biosynthetic Process
Positive Regulation Of Calcidiol 1-monooxygenase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Deacetylation
Extrinsic Apoptotic Signaling Pathway
Neuroinflammatory Response
Negative Regulation Of Amyloid-beta Clearance
Positive Regulation Of Neuron Death
Positive Regulation Of Cellular Respiration
Positive Regulation Of Amyloid-beta Formation
Negative Regulation Of Tau-protein Kinase Activity
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Exosomal Secretion
Positive Regulation Of Iron Ion Import Across Plasma Membrane
Positive Regulation Of NMDA Glutamate Receptor Activity
Positive Regulation Of Core Promoter Binding
Positive Regulation Of Signaling Receptor Activity
Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production
Pathways
Downstream signal transduction
STAT6-mediated induction of chemokines
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Olsalazine
Glucosamine
VIR201
Fontolizumab
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Emapalumab
Diseases
Graft-versus-host disease
Allograft rejection
GWAS
Adult asthma (
30787307
)
Alcohol consumption (
31358974
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
31361310
)
Allergic sensitization (
30013184
23817571
)
Allergy (
27182965
)
Asthma (
31361310
31959851
30929738
27182965
32296059
31619474
29273806
)
Asthma (adult onset) (
31036433
30929738
)
Asthma (childhood onset) (
31036433
30929738
)
Asthma (moderate or severe) (
30552067
)
Asthma onset (childhood vs adult) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Bipolar disorder (
31043756
)
Bitter alcoholic beverage consumption (
31046077
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Eosinophilic esophagitis (
25407941
)
Eosinophilic esophagitis (pediatric) (
20208534
)
Familial lung cancer (
29924316
)
Headache (
29397368
)
Height (
31562340
)
IgE levels (
22075330
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Medication use (adrenergics, inhalants) (
31015401
)
Medication use (anti-inflammatory and antirheumatic products, non-steroids) (
31015401
)
Medication use (antihistamines for systemic use) (
31015401
)
Migraine (
27322543
)
Migraine without aura (
27322543
)
Mosquito bite size (
28199695
)
Neutrophil percentage of granulocytes (
27863252
)
Perceived unattractiveness to mosquitoes (
28199695
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Sensory disturbances after bilateral sagittal split ramus osteotomy (
23834954
)
Sum eosinophil basophil counts (
27863252
)
Alopecia areata (
25608926
)
Anti-saccade response (
29064472
)
Inflammatory bowel disease (
23128233
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Systemic lupus erythematosus (
28714469
)
Ulcerative colitis (
20228799
21297633
19122664
)
Interacting Genes
38 interacting genes:
ANKZF1
ANXA2
CEBPB
CEBPE
CEBPZ
CREBBP
DAZAP2
EEF1A1
EP300
ETS1
FBXO7
H3C14
IFNG
IL4R
IRF4
JAK1
LITAF
NCOA1
NCOA2
NFKB1
NMI
PPARG
PRKCZ
PTPN6
RCN3
RELA
RLIM
SND1
SRC
STAT2
STAT3
TP53
TRIM24
VKORC1
WWP1
ZBTB2
ZNF407
ZNF92
5 interacting genes:
IFNGR1
IFNGR2
PDIA3
STAT6
TNF
Entrez ID
6778
3458
HPRD ID
03302
00957
Ensembl ID
ENSG00000166888
ENSG00000111537
Uniprot IDs
A8K4S9
B4DQB3
H0YJH6
P42226
P01579
PDB IDs
1OJ5
4Y5U
4Y5W
5D39
5NWM
5NWX
1EKU
1FG9
1FYH
1HIG
3BES
6E3K
6E3L
Enriched GO Terms of Interacting Partners
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