SRPK2 and DDX21

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		SRPK2	DDX21
Description		SRSF protein kinase 2	DExD-box helicase 21
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck	Nucleoplasm Chromosome Nucleolus Mitochondrion Cytosol Membrane
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding 14-3-3 Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	MAPK Cascade Spliceosomal Complex Assembly Angiogenesis Protein Phosphorylation Positive Regulation Of Cell Population Proliferation RNA Splicing Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Cell Differentiation Nuclear Speck Organization Intracellular Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing R-loop Disassembly	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus R-loop Disassembly
Pathways			B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) General cognitive ability ( 29844566) Myopia (pathological) ( 23049088) Regular attendance at a religious group ( 29970889) Schizophrenia ( 28991256 25056061 29483656 30285260) Uterine fibroid size (maximum dimension) ( 30196971) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Youthful appearance (self-reported) ( 32339537)	Depression (quantitative trait) ( 20800221)
Interacting Genes		421 interacting genes: ABL1 ACIN1 ACTB ACTG1 ADAMTS18 ADGRG5 ADPRH AHCYL1 AKAP13 AKT1 ALDOA ALKBH3 ALPL AMER1 AMMECR1L ANK3 ANKFY1 ANKRD35 AP1M1 APEX1 APOBEC3C APP ARFGEF3 ARGLU1 ARHGAP12 ARL6IP4 ARPC1B ARSG ASL ATAT1 AURKA BAG3 BAIAP2 BAZ1A BCL9L BCLAF1 BUD13 C16orf78 C18orf25 C1orf35 C4orf46 CACNG2 CADPS2 CALCOCO1 CAMSAP1 CAND1 CARD11 CARHSP1 CASK CBLN4 CBX5 CCDC28A CCDC86 CCDC88B CCDC97 CCM2 CDC42EP4 CDK12 CDK13 CDK7 CEP170 CHD1L CHD2 CHEK2 CHERP CHTOP CHUK CLASP1 CLASP2 CLASRP CLCNKA CLDN19 CLK1 CLK2 CLK3 CLU COIL CPLANE1 CPSF7 CRTC1 CSAG1 CTNNBL1 DAW1 DBF4B DCAF10 DDX21 DDX39B DDX3X DDX46 DDX50 DDX6 DHX8 DIDO1 DNAH6 DNAH9 DNAJC8 DOCK3 DRAP1 DRG1 ECT2 EED EFCAB12 EGLN2 EIF1AY EIF3A EIF4B EIF4G1 ELAVL3 ELP6 ENOX2 ENSA EPB41L1 EPB41L4A EPB41L4B EPM2A EPS8L1 EPS8L3 ERBB3 ERC1 ERCC3 ERN1 EVI5L F5 FAM43A FAM76B FAM90A1 FBXO24 FCHO1 FGF12 FGFR3 FIP1L1 FMNL1 FOXN3 FXR1 GABARAP GABARAPL1 GBF1 GCC2 GGCX GHR GLRA4 GNGT2 GSE1 GTF2E1 GTPBP4 GXYLT2 H2BC12 HBS1L HERC3 HIRIP3 HIVEP1 HMCN2 HMGA1 HMGN2 HMGN3 HMGXB4 HNRNPA1 HNRNPA3 HNRNPC HNRNPK HOMER3 HOXB6 HTATSF1 IFIT5 IRS2 ISLR JMJD1C KANK2 KCNN2 KHDRBS1 KIF11 KRT78 LBR LCA5 LCE3D LDHC LGMN LINC00322 LMNA LMNB1 LMO7 LRRC34 LRRC52 LRRN4CL LUC7L3 LUZP4 MAB21L2 MACF1 MACO1 MAGEB1 MAP1S MAP3K20 MAP4 MAP7 MAP7D1 MAPKAPK3 MAPKAPK5 MAPRE1 MAPT MARCHF10 MAST2 MATR3 MCOLN3 MDC1 MDK MFSD10 MIB2 MIPOL1 MMP23B MPP3 MRPS6 MTCL1 MYCBP2 MYLIP MYO18B MYO1E MZT2B NADK NAGK NCBP3 NCK2 NCL NELFE NGDN NGLY1 NKAP NOLC1 NOM1 NOP16 NOP53 NPM2 NSMCE4A NSRP1 NSUN5P2 NTHL1 NUP50 NXF1 NXPE4 NXT2 OBI1 OCEL1 OTOF PABPC4 PAK4 PALLD PCBP1 PCF11 PDCL3 PDE7B PELI1 PHF6 PHLDB1 PKD1L2 PLEKHA5 PNISR PNMA8B PNN POLB POLDIP3 PPHLN1 PPIA PPIL1 PPP1R13L PRKAA1 PRPF38A PRPF38B PRPF40A PRPF4B PRR20A PRR20B PRR20C PRR20D PRR20E PRRC2A PRRC2B PRRC2C PSMA3 PSMD13 PTBP1 PTPN22 RABEP1 RASGRF1 RBM15 RBM15B RBM19 RBM23 RBM39 RBM8A RBMX RIPK3 RIT1 RIT2 RNF4 RNPS1 RPL13 RPL22 RPL34 RPL37 RPL39L RPL41 RPLP2 RPS26 RRM2B RRP1 RRP1B RSL1D1 RSRC1 RSRC2 RSRP1 RTF1 RWDD2B RXFP1 S100A4 SAFB SART1 SBK1 SCAF1 SDK2 SDR42E1 SEC16B SEC23B SELENOS SERPING1 SGPL1 SIPA1L3 SLAIN2 SLC13A2 SLC17A6 SLFN5 SLTM SMCHD1 SNIP1 SNRNP27 SNRNP35 SNRNP70 SNURF SON SPDEF SPEN SRC SREK1 SRI SRRM1 SRRM2 SRSF1 SRSF11 SRSF12 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF8 SRSF9 SRXN1 STON1 SUPT16H SYCP2 TAF7L TCEANC2 TCOF1 TDP2 TJP2 TLE4 TLE5 TMPO TMPRSS11A TMSB10 TNFAIP8L2 TNFRSF10C TNIP2 TNS3 TOGARAM1 TOP1 TPD52 TRA2A TRA2B TRIM41 TRIP12 TTN TUBA1B TXN U2AF2 UBD UBE2E2 UBR4 UPF3B USP36 USP39 VAC14 VAV2 VRK1 VSTM2L WDR24 WDR5 WDR70 XRCC5 YBX3 YPEL2 YPEL3 YRDC YTHDC1 YTHDC2 ZC3H13 ZCCHC17 ZDHHC5 ZFC3H1 ZFHX4 ZFP91 ZMAT4 ZMYM4 ZNF140 ZNF234 ZNF529 ZNF592 ZNF593 ZNF616 ZRANB2 ZRSR2 ZSCAN12 ZSCAN9	87 interacting genes: CALM1 CSNK2A1 DUX4 ERG H2AX IL7R JUN KPNA3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PIAS1 PTEN SRPK2 SUMO2 TERF1 TERF2 UBE2I
Entrez ID		6733	9188
HPRD ID		04280	05895
Ensembl ID		ENSG00000135250	ENSG00000165732
Uniprot IDs		A0A024R704 P78362	Q9NR30
PDB IDs		2X7G 5MYV	2M3D 6L5L 6L5M 6L5N 6L5O
Enriched GO Terms of Interacting Partners?
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