SRP14 and EAF1

Data Source:
BioGRID (two hybrid)

		SRP14	EAF1
Description		signal recognition particle 14	ELL associated factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Super Elongation Complex Intracellular Membrane-bounded Organelle Intercellular Bridge
	Molecular Function	RNA Binding Protein Binding 7S RNA Binding Endoplasmic Reticulum Signal Peptide Binding	Transcription Elongation Regulator Activity Protein Binding
	Biological Process	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Neutrophil Degranulation Protein Targeting To ER	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Neutrophil degranulation	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs		Artenimol
Diseases
GWAS		Ewing sarcoma ( 22327514) Obesity-related traits ( 23251661) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		7 interacting genes: CALM1 EAF1 IL7R NSFL1C PTEN SPANXN2 SRP9	53 interacting genes: AP2M1 APP ARID4B BEND7 BHLHB9 CCDC150 CCDC33 CEP70 CEP76 DNTTIP1 DPPA4 ELL ELL2 ELL3 FAM228A GADD45GIP1 GAS8 GCSAML GOLGA6L9 GRHL3 GTF2H1 GTF2H4 HOMER3 HSF2BP KEAP1 KIAA1328 MAB21L3 MIPOL1 NUMB PAX6 PICK1 PIH1D1 PSME3 RYBP SDCBP SEMG1 SH3RF1 SRP14 STAC3 TCEA2 TFCP2 TFPT TLE5 TNFAIP8 TNNI1 TRAF2 TRIM62 VAX1 YAF2 ZBTB14 ZNF143 ZNF202 ZNF620
Entrez ID		6727	85403
HPRD ID		02831	12209
Ensembl ID		ENSG00000140319	ENSG00000144597
Uniprot IDs		P37108	Q96JC9
PDB IDs		1E8O 1E8S 1RY1 4UYJ 4UYK 5AOX
Enriched GO Terms of Interacting Partners?
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