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SPN and ICAM1
Data Source:
HPRD
(in vitro)
SPN
ICAM1
Description
sialophorin
intercellular adhesion molecule 1
Image
No pdb structure
GO Annotations
Cellular Component
Uropod
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Microvillus
External Side Of Plasma Membrane
Cell Surface
Membrane
PML Body
Extracellular Exosome
Immunological Synapse
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Membrane Raft
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Virus Receptor Activity
Transmembrane Signaling Receptor Activity
Integrin Binding
Protein Binding
Signaling Receptor Activity
Biological Process
T-helper 1 Cell Lineage Commitment
Chemotaxis
Immune Response
Cellular Defense Response
Negative Regulation Of Cell Adhesion
Establishment Or Maintenance Of Cell Polarity
Signal Transduction
Cell Surface Receptor Signaling Pathway
Interferon-gamma Production
Positive Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of T Cell Proliferation
Defense Response To Bacterium
Regulation Of Immune Response
Leukocyte Migration
Leukocyte Tethering Or Rolling
Regulation Of T Cell Migration
Positive Regulation Of T Cell Migration
Ovarian Follicle Development
Regulation Of Leukocyte Mediated Cytotoxicity
Response To Amphetamine
T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Acute Inflammatory Response To Antigenic Stimulus
T Cell Antigen Processing And Presentation
Positive Regulation Of Cellular Extravasation
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell Aging
Sensory Perception Of Sound
Regulation Of Cell Shape
Response To Ionizing Radiation
Response To Sulfur Dioxide
Cytokine-mediated Signaling Pathway
Membrane To Membrane Docking
Extracellular Matrix Organization
Positive Regulation Of Actin Filament Polymerization
Cellular Response To Nutrient Levels
Response To Insulin
Cell Adhesion Mediated By Integrin
Response To Gonadotropin
Response To Drug
Response To Amino Acid
Positive Regulation Of GTPase Activity
Adhesion Of Symbiont To Host
Positive Regulation Of Nitric Oxide Biosynthetic Process
Response To Ethanol
Positive Regulation Of Vasoconstriction
Response To Copper Ion
Viral Entry Into Host Cell
Receptor-mediated Virion Attachment To Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Leukocyte Migration
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Calcium Ion Transport
Interferon-gamma-mediated Signaling Pathway
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Alkaloid
Cellular Response To Glucose Stimulus
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Dexamethasone Stimulus
T Cell Extravasation
Establishment Of Endothelial Intestinal Barrier
Establishment Of Sertoli Cell Barrier
Regulation Of Ruffle Assembly
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Cellular Response To Amyloid-beta
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Cell surface interactions at the vascular wall
Basigin interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Drugs
Natalizumab
Hyaluronic acid
Nafamostat
Diseases
Allograft rejection
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Crohn's disease (
21102463
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
Low white blood cell count (conditioned on rs2814778) (
29596498
)
Lymphocyte counts (
32888494
27863252
)
Monocyte count (
32888494
)
Pulse pressure (
27841878
)
Soluble ICAM-1 (
21533024
31217265
18604267
)
White blood cell count (
32888494
)
Interacting Genes
18 interacting genes:
ARL13B
CLCA4
CTNNB1
CTSA
CXCL16
CYBC1
DAXX
ERGIC3
EZR
FYN
ICAM1
LGALS1
LMNA
MSN
PLP2
SGTA
SIGLEC1
UBQLN2
16 interacting genes:
CYSRT1
EGFR
EZR
FGG
HSD3B7
IL2RA
IL2RG
ITGAL
ITGAM
ITGB2
KEAP1
KRTAP10-8
MSN
SLC3A2
SPN
UBQLN2
Entrez ID
6693
3383
HPRD ID
06770
00996
Ensembl ID
ENSG00000197471
ENSG00000090339
Uniprot IDs
A0A024R629
P16150
A0A384MEK5
P05362
PDB IDs
1D3E
1D3I
1D3L
1IAM
1IC1
1IJ4
1MQ8
1P53
1Z7Z
2OZ4
3TCX
5MZA
6EIT
6S8U
Enriched GO Terms of Interacting Partners
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