SPAST and CHMP1B

Data Source:
BioGRID (two hybrid, pull down)

		SPAST	CHMP1B
Description		spastin	charged multivesicular body protein 1B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Microtubule Microtubule Cytoskeleton Integral Component Of Membrane Midbody Cytoplasmic Vesicle Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Axon Cytoplasm	ESCRT III Complex Nucleoplasm Multivesicular Body Cytosol Endosome Membrane Membrane Coat Midbody Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity ATPase Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Mitotic Cytokinesis Microtubule Bundle Formation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Axonogenesis Anterograde Axonal Transport Metabolic Process Exit From Mitosis Axonal Transport Of Mitochondrion Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Nuclear Envelope Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cytoskeleton-dependent Cytokinesis Membrane Fission	Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization Late Endosome To Vacuole Transport Cell Division Midbody Abscission Regulation Of Mitotic Spindle Assembly ESCRT III Complex Disassembly
Pathways		Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Apolipoprotein A1 levels ( 32203549) Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: CHMP1B IST1 RTN1 SSNA1	19 interacting genes: CHMP1A CHMP4B CHMP5 CNOT10 KNSTRN MITD1 PICK1 RAB11A RASSF7 SNRNP200 SPAST SSRP1 STAMBP SUCLG1 USP54 USP8 VPS4A VPS4B VTA1
Entrez ID		6683	57132
HPRD ID		05044	12106
Ensembl ID		ENSG00000021574	ENSG00000255112
Uniprot IDs		E5KRP5 E5KRP6 Q9UBP0	Q7LBR1
PDB IDs		3EAB 3VFD 5Z6Q 5Z6R 6PEK 6PEN	3EAB 3JC1 4TXQ 4TXR 6E8G 6TZ4 6TZ5 6TZ9
Enriched GO Terms of Interacting Partners?
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