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SPARC and COL2A1
Data Source:
HPRD
(in vitro)
SPARC
COL2A1
Description
secreted protein acidic and cysteine rich
collagen type II alpha 1 chain
Image
GO Annotations
Cellular Component
Extracellular Region
Basement Membrane
Extracellular Space
Cytoplasm
Mitochondrion
Plasma Membrane
Cell Surface
Nuclear Matrix
Platelet Alpha Granule
Platelet Alpha Granule Membrane
Platelet Alpha Granule Lumen
Intracellular Membrane-bounded Organelle
Collagen-containing Extracellular Matrix
Endocytic Vesicle Lumen
Glutamatergic Synapse
Extracellular Region
Collagen Trimer
Collagen Type II Trimer
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Collagen Binding
Extracellular Matrix Binding
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
MHC Class II Protein Binding
Identical Protein Binding
Proteoglycan Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Ossification
Negative Regulation Of Endothelial Cell Proliferation
Platelet Degranulation
Receptor-mediated Endocytosis
Heart Development
Response To Gravity
Response To Lead Ion
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Angiogenesis
Regulation Of Cell Morphogenesis
Extracellular Matrix Organization
Lung Development
Response To Lipopolysaccharide
Response To L-ascorbic Acid
Response To Cytokine
Wound Healing
Response To Peptide Hormone
Response To Ethanol
Response To Cadmium Ion
Inner Ear Development
Anatomical Structure Development
Regulation Of Synapse Organization
Response To Glucocorticoid
Response To CAMP
Response To Calcium Ion
Skeletal System Development
Cartilage Condensation
Tissue Homeostasis
Endochondral Ossification
Chondrocyte Differentiation
Heart Morphogenesis
Proteoglycan Metabolic Process
Central Nervous System Development
Visual Perception
Sensory Perception Of Sound
Regulation Of Gene Expression
Extracellular Matrix Organization
Collagen Fibril Organization
Notochord Development
Inner Ear Morphogenesis
Regulation Of Immune Response
Cartilage Development
Roof Of Mouth Development
Limb Bud Formation
Embryonic Skeletal Joint Morphogenesis
Cartilage Development Involved In Endochondral Bone Morphogenesis
Otic Vesicle Development
Cellular Response To BMP Stimulus
Anterior Head Development
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Platelet degranulation
Nuclear signaling by ERBB4
ECM proteoglycans
Scavenging by Class H Receptors
Collagen degradation
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Drugs
Calcium citrate
Calcium Phosphate
Calcium phosphate dihydrate
Collagenase clostridium histolyticum
Diseases
Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
Osteoarthritis with mild chondrodysplasia
GWAS
Lymphocyte counts (
32888494
)
Macular thickness (
30535121
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Retinal detachment or retinal break (
31816047
)
Rheumatoid arthritis (
30891314
)
Interacting Genes
22 interacting genes:
COL13A1
COL1A1
COL1A2
COL2A1
COL3A1
COL5A1
CPEB2
CTSK
FN1
HSPG2
PDGFA
PDGFB
PLAT
PLG
SDC2
TGFB1
TGM2
THBS1
UBQLN1
VEGFA
XRCC6
ZNF579
33 interacting genes:
ANXA5
BGN
BMP2
C1QA
CHAD
COL6A1
COL9A2
COL9A3
COMP
DDR1
FGF7
FN1
HTRA1
HYAL1
ITGA2B
KEAP1
LOXL4
MAG
MATN1
MMP1
MMP13
PCOLCE
PDGFA
PDGFB
PDIA2
PKD1
PRELP
RELA
SPARC
TGFB1
TGFBI
THBS1
TNFRSF10A
Entrez ID
6678
1280
HPRD ID
01631
00361
Ensembl ID
ENSG00000113140
ENSG00000139219
Uniprot IDs
P09486
P02458
PDB IDs
1BMO
1NUB
1SRA
2V53
1U5M
2FSE
2SEB
5NIR
5OCX
5OCY
6BIN
6NIX
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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