COL2A1 and HYAL1

Data Source:
BioGRID (two hybrid)

		COL2A1	HYAL1
Description		collagen type II alpha 1 chain	hyaluronidase 1
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Space Cytoplasm Lysosome Cytoplasmic Vesicle Hyaluranon Cable Lysosomal Lumen Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength MHC Class II Protein Binding Identical Protein Binding Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Virus Receptor Activity Hyalurononglucosaminidase Activity Transcription Factor Binding Hyaluronan Synthase Activity
	Biological Process	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Organization Collagen Fibril Organization Notochord Development Inner Ear Morphogenesis Regulation Of Immune Response Cartilage Development Roof Of Mouth Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Anterior Head Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Reactive Oxygen Species Carbohydrate Metabolic Process Inflammatory Response Response To Virus Positive Regulation Of Epithelial Cell Migration Chondroitin Sulfate Catabolic Process Hyaluronan Metabolic Process Hyaluronan Biosynthetic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Growth Response To Antibiotic Viral Entry Into Host Cell Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Embryonic Skeletal Joint Morphogenesis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To PH Cellular Response To UV-B Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Hyaluranon Cable Assembly
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization	CS/DS degradation Hyaluronan uptake and degradation MPS IX - Natowicz syndrome
Drugs		Collagenase clostridium histolyticum
Diseases		Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Osteoarthritis with mild chondrodysplasia	Mucopolysaccharidosis type IX (MPS9); Hyaluronidase deficiency
GWAS		Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis ( 30891314)	Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Sleep duration (short sleep) ( 30846698)
Interacting Genes		33 interacting genes: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B KEAP1 LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A	1 interacting genes: COL2A1
Entrez ID		1280	3373
HPRD ID		00361	06146
Ensembl ID		ENSG00000139219	ENSG00000114378
Uniprot IDs		P02458	A0A024R2X3 A0A0S2Z3Q0 B3KUI5 Q12794
PDB IDs		1U5M 2FSE 2SEB 5NIR 5OCX 5OCY 6BIN 6NIX	2PE4
Enriched GO Terms of Interacting Partners?
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