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SNX1 and F2R
Data Source:
HPRD
(in vitro, in vivo)
SNX1
F2R
Description
sorting nexin 1
coagulation factor II thrombin receptor
Image
GO Annotations
Cellular Component
Cytoplasm
Lysosome
Endosome
Golgi Apparatus
Cytosol
Endosome Membrane
Membrane
Lamellipodium
Retromer Complex
Retromer, Tubulation Complex
Early Endosome Membrane
Vesicle
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Extracellular Region
Early Endosome
Late Endosome
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Cell Surface
Platelet Dense Tubular Network
Neuromuscular Junction
Postsynaptic Membrane
Molecular Function
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Protein Binding
Phosphatidylinositol Binding
Identical Protein Binding
Protein Homodimerization Activity
Cadherin Binding
Protein Heterodimerization Activity
Transferrin Receptor Binding
Leptin Receptor Binding
G-protein Alpha-subunit Binding
G Protein-coupled Receptor Activity
Signaling Receptor Binding
Protein Binding
Thrombin-activated Receptor Activity
G-protein Beta-subunit Binding
Biological Process
Intracellular Protein Transport
Receptor Internalization
Early Endosome To Golgi Transport
Retrograde Transport, Endosome To Golgi
Positive Regulation Of Protein Catabolic Process
Lamellipodium Morphogenesis
Activation Of MAPKK Activity
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Negative Regulation Of Glomerular Filtration
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Establishment Of Synaptic Specificity At Neuromuscular Junction
Blood Coagulation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Wounding
Anatomical Structure Morphogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Platelet Activation
Regulation Of Blood Coagulation
Positive Regulation Of Blood Coagulation
Positive Regulation Of Cell Migration
Response To Lipopolysaccharide
Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Rho Protein Signal Transduction
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Cell-cell Junction Maintenance
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Vasoconstriction
Positive Regulation Of Smooth Muscle Contraction
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Homeostasis Of Number Of Cells Within A Tissue
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Positive Regulation Of Calcium Ion Transport
Regulation Of Sensory Perception Of Pain
Platelet Dense Granule Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Thrombin-activated Receptor Signaling Pathway
Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission
Negative Regulation Of Renin Secretion Into Blood Stream
Pathways
Common Pathway of Fibrin Clot Formation
Peptide ligand-binding receptors
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
Thrombin signalling through proteinase activated receptors (PARs)
Drugs
Streptokinase
SR-123781A
Vorapaxar
Thrombin
Diseases
GWAS
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Erosive tooth wear (severe vs non-severe) (
29898447
)
Erosive tooth wear (severe vs none or mild) (
29898447
)
Mean platelet volume (
22139419
)
Platelet count (
22139419
)
Platelet distribution width (
27863252
)
Interacting Genes
48 interacting genes:
ACVR1B
ACVR2B
AGTRAP
APP
ARFIP2
ARL6IP1
ARMC12
ATXN7
CCDC148
CHRNG
CMTM4
CMTM5
COQ3
EGFR
F2R
FAM25A
FAM25C
FAM25G
FKBP7
FUNDC1
HCCS
HGS
INSR
LEPR
LIME1
MPC2
PDGFRB
PLIN3
RABAC1
REEP5
REEP6
RHEX
RTN3
RTN4
SASH1
SDCBP
SDR16C5
SFT2D1
SH3GLB1
SNX2
SNX32
SNX6
SYNGR1
SYP
TK1
TMEM239
UFD1
VPS35
19 interacting genes:
ARRDC3
ATP13A2
CAPN1
CHRD
CTSG
CXCL14
ELANE
F2
GNA12
GNA13
GNA15
GNAI2
GNAT1
GPRASP1
ITGAV
PDCD6IP
PLG
PRTN3
SNX1
Entrez ID
6642
2149
HPRD ID
03171
01763
Ensembl ID
ENSG00000028528
ENSG00000181104
Uniprot IDs
Q13596
A0A024RAP7
P25116
PDB IDs
2I4K
4FZS
1NRN
1NRO
1NRP
1NRQ
1NRR
3BEF
3HKI
3HKJ
3LU9
3VW7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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