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SMN2 and SNRPB
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HPRD
(in vitro)
SMN2
SNRPB
Description
survival of motor neuron 2, centromeric
small nuclear ribonucleoprotein polypeptides B and B1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cajal Body
Nuclear Body
Z Disc
Axon
SMN Complex
SMN-Sm Protein Complex
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Perikaryon
Gemini Of Coiled Bodies
Nucleus
Nucleoplasm
Spliceosomal Complex
U5 SnRNP
U7 SnRNP
U1 SnRNP
U2 SnRNP
U4 SnRNP
U12-type Spliceosomal Complex
Telomerase Holoenzyme Complex
Cytoplasm
Cytosol
Small Nuclear Ribonucleoprotein Complex
Methylosome
SMN-Sm Protein Complex
U4/U6 X U5 Tri-snRNP Complex
U2-type Prespliceosome
U2-type Precatalytic Spliceosome
U2-type Catalytic Step 2 Spliceosome
Catalytic Step 2 Spliceosome
Histone Pre-mRNA 3'end Processing Complex
Molecular Function
RNA Binding
Protein Binding
Identical Protein Binding
RNA Binding
Protein Binding
Telomerase RNA Binding
Histone Pre-mRNA DCP Binding
U1 SnRNP Binding
U2 SnRNP Binding
Biological Process
Spliceosomal Complex Assembly
Spliceosomal SnRNP Assembly
DNA-templated Transcription, Termination
Nervous System Development
Import Into Nucleus
Spliceosomal SnRNP Assembly
MRNA Splicing, Via Spliceosome
Termination Of RNA Polymerase II Transcription
Protein Methylation
Brain Development
Histone MRNA Metabolic Process
RNA Splicing
Import Into Nucleus
Pathways
snRNP Assembly
SLBP independent Processing of Histone Pre-mRNAs
snRNP Assembly
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
RNA Polymerase II Transcription Termination
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Drugs
Nusinersen
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes
36 interacting genes:
BLOC1S6
BYSL
CHTOP
DDX20
DHX9
EHHADH
FAM9B
FBL
FNDC11
GAR1
GEMIN2
HNRNPUL1
IQUB
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-1
KRTAP6-2
MAGED1
POLR1C
POLR2A
PPIG
SMN1
SNRPB
SNRPB2
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SNRPG
SNU13
SPANXN2
TIAL1
USP9X
VPS28
89 interacting genes:
AKAP9
ASCC2
BAG4
BANP
C10orf55
CALCOCO2
CD2BP2
CDKN2A
CEP55
CLNS1A
COA7
COG6
COIL
CREM
CTDP1
CYSRT1
DAB1
DDX20
DHX9
ERG28
EXOSC8
FAM168B
FHL3
FNBP4
FUBP1
GEMIN4
GEMIN5
GEMIN6
GEMIN7
GIGYF1
GIGYF2
GOLGA2
HNRNPH1
HOXA1
IL7R
INCA1
KRT34
KRT40
KRTAP19-1
KRTAP19-6
KRTAP6-1
KRTAP6-2
KRTAP6-3
L3MBTL3
LSM11
LSM8
MAGI2
MBD3L1
OIP5
OOEP
PFDN5
PLEKHB2
PNMA1
PRMT5
PRMT7
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PRR22
PSMA3
RBPMS
RFX6
SERTAD3
SKIV2L
SMN1
SMN2
SMNDC1
SNRPD1
SNRPD3
SNUPN
SP3
SPAG8
SS18L1
STRAP
STXBP2
STXBP3
TFIP11
TOP3B
TRAF4
TRIM23
UBQLN2
UBXN11
USP54
WBP4
WDR77
WWP2
ZNF143
Entrez ID
6607
6628
HPRD ID
09036
01655
Ensembl ID
ENSG00000205571
ENSG00000125835
Uniprot IDs
B4DP61
E7EQZ4
Q16637
P14678
Q66K91
PDB IDs
1G5V
1MHN
2LEH
4A4E
4A4G
4GLI
4QQ6
5XJL
5XJQ
5XJR
5XJS
5XJT
5XJU
1D3B
3CW1
3JCR
3PGW
4PJO
4WZJ
5MQF
5O9Z
5XJC
5YZG
5Z56
5Z57
5Z58
6AH0
6FF7
6ICZ
6ID0
6ID1
6QDV
6QW6
6QX9
6V4X
6Y53
6Y5Q
7A5P
Enriched GO Terms of Interacting Partners
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