SMN2 and GAR1

Data Source:
HPRD (in vivo, in vitro)

		SMN2	GAR1
Description		survival of motor neuron 2, centromeric	GAR1 ribonucleoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Perikaryon Gemini Of Coiled Bodies	Chromosome, Telomeric Region Fibrillar Center Nucleoplasm Telomerase Holoenzyme Complex Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	RNA Binding Protein Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Nervous System Development Import Into Nucleus	SnoRNA Guided RRNA Pseudouridine Synthesis Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis
Pathways		snRNP Assembly	Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs		Nusinersen
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes		36 interacting genes: BLOC1S6 BYSL CHTOP DDX20 DHX9 EHHADH FAM9B FBL FNDC11 GAR1 GEMIN2 HNRNPUL1 IQUB KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 MAGED1 POLR1C POLR2A PPIG SMN1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNU13 SPANXN2 TIAL1 USP9X VPS28	3 interacting genes: NEAT1 SMN1 SMN2
Entrez ID		6607	54433
HPRD ID		09036	07569
Ensembl ID		ENSG00000205571	ENSG00000109534
Uniprot IDs		B4DP61 E7EQZ4 Q16637	Q9NY12
PDB IDs		1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU
Enriched GO Terms of Interacting Partners?
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