SMARCE1 and IFT88

Data Source:
BioGRID (two hybrid)

		SMARCE1	IFT88
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	intraflagellar transport 88
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Nucleus Nucleoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex	Cytoplasm Centrosome Centriole Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Sperm Flagellum Ciliary Tip Ciliary Base Non-motile Cilium
	Molecular Function	Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding N-acetyltransferase Activity Nuclear Receptor Binding Nucleosomal DNA Binding Protein N-terminus Binding	Protein Binding Kinesin Binding
	Biological Process	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Neurogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Kidney Development Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Cilium Assembly Non-motile Cilium Assembly Regulation Of Autophagosome Assembly
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Hedgehog 'off' state Intraflagellar transport Intraflagellar transport Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eczema ( 31361310)	Coronary artery calcification ( 23870195) Dental caries ( 23064961) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Sulfasalazine-induced agranulocytosis ( 28762467)
Interacting Genes		89 interacting genes: AMOTL2 AR ARID2 BAZ1B BRAP BRMS1 CCDC136 CCDC172 CCDC183 CCHCR1 CDR2 CEP170P1 CEP63 CEP70 CYSRT1 DISC1 EPS8 ESR1 ESR2 EXOC4 EXOC7 FAM217B FSD2 GATA1 GOLGA2 GOLGA6L9 GRIPAP1 IFT74 IFT88 ING5 ITCH JAKMIP2 KIFC3 KLF1 KRT14 KRT15 KRT16 KRT19 KRT27 KRT31 KRT34 KRT35 KRT37 KRT39 KRT40 KRTAP1-1 KRTAP10-8 KRTAP10-9 KRTAP6-3 MDM2 MED4 MEOX2 MIPOL1 MRFAP1L1 MTUS2 NBPF22P NCOA1 NCOA2 NCOA3 NOTCH2NLA NR0B2 NR3C1 NUP62 OIP5 PGR PRMT5 PSMC6 RALBP1 RARB RCOR1 RELB RINT1 SIN3A SIN3B SMAD1 SMARCA4 SPAG5 SRC STX11 SYCE1 TEX12 TFE3 TFIP11 TNIK TRIM54 TRIP10 TXLNA USHBP1 VPS52	10 interacting genes: CAPN7 CCDC120 EEF2KMT EML2 FBXO7 ITPKB MSRB1 PRRC2A RPGR SMARCE1
Entrez ID		6605	8100
HPRD ID		04382	09000
Ensembl ID		ENSG00000073584	ENSG00000032742
Uniprot IDs		A0A024R1S7 Q969G3	A0A140VJL7 B3KX42 Q13099
PDB IDs		6LTH 6LTJ 7CYU
Enriched GO Terms of Interacting Partners?
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