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SLPI and GRN
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, two hybrid, in vivo)
SLPI
GRN
Description
secretory leukocyte peptidase inhibitor
granulin precursor
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Apparatus
Specific Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Azurophil Granule Lumen
Extracellular Exosome
Molecular Function
DNA Binding
MRNA Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Enzyme Binding
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Chaperone Binding
Biological Process
Immune Response
Negative Regulation Of Endopeptidase Activity
Antibacterial Humoral Response
Negative Regulation Of Protein Binding
Response To Lipopolysaccharide
Modulation Of Process Of Other Organism
Neutrophil Degranulation
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Neutrophil Degranulation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Axon Regeneration
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Protein Stabilization
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Aspartic-type Peptidase Activity
Positive Regulation Of Lysosome Organization
Pathways
Neutrophil degranulation
Neutrophil degranulation
Drugs
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS
Bipolar disorder (
31043756
)
Blood protein levels (
30072576
28240269
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Malaria (
31844061
)
Blood protein levels (
30072576
29875488
)
Brain morphology (MOSTest) (
32665545
)
Intracranial volume (
22504418
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
Interacting Genes
25 interacting genes:
CALN1
CIB3
CTSB
CTSL
CTSS
EFEMP1
ELANE
FAM9B
GRN
HOXA1
KLK3
LAT
MAPK8IP2
MICOS10-NBL1
MKRN3
NBL1
NTAQ1
PIH1D2
PLSCR1
PRSS2
SGTA
SGTB
SMIM14
UBQLN1
UBQLN2
79 interacting genes:
ARFGAP1
ATN1
ATXN7
C22orf39
C4orf17
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CLPP
CRCT1
CRKL
CRY1
CXCL5
CYSRT1
DLK1
DLX2
DMRT3
ECM1
ELANE
FAM131C
FAM76B
FANCL
FRAT1
GFI1B
GLRX3
GNE
HK3
HOXA1
HSPG2
KRT18
KRT34
KRTAP1-1
KRTAP1-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP26-1
KRTAP5-9
KRTAP6-1
KRTAP6-2
LCE1A
LCE1D
LCE1E
LCE2B
LCE2D
LCE3C
LCE3E
LCE4A
MEOX2
NLK
NUFIP2
OTX1
P4HB
PIK3R2
PLLP
POT1
POU4F2
PRKAB2
PTPMT1
RAC1
SGTA
SLC13A1
SLPI
SMAD9
SMCP
SPRY2
TAT
TGM2
TLE5
TOP3B
TSPAN4
UTP23
VASN
YY1
Entrez ID
6590
2896
HPRD ID
00121
00733
Ensembl ID
ENSG00000124107
ENSG00000030582
Uniprot IDs
P03973
P28799
PDB IDs
2Z7F
4DOQ
1G26
2JYE
2JYT
2JYU
2JYV
6NUG
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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