BMP7 and KRTAP5-9

Data Source:
BioGRID (two hybrid, two hybrid)

		BMP7	KRTAP5-9
Description		bone morphogenetic protein 7	keratin associated protein 5-9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle Collagen-containing Extracellular Matrix	Cytosol Keratin Filament
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding BMP Receptor Binding	Protein Binding Identical Protein Binding
	Biological Process	Skeletal System Development Ossification Metanephros Development Ureteric Bud Development Mesoderm Formation Mesonephros Development Epithelial To Mesenchymal Transition Endocardial Cushion Formation Pericardium Morphogenesis Axon Guidance Embryonic Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Dendrite Development Neural Fold Elevation Formation Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Hindbrain Development Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Protein Localization To Nucleus Negative Regulation Of Phosphorylation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Response To Peptide Hormone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Cardiac Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cartilage Development Pharyngeal System Development Embryonic Skeletal Joint Morphogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Cell Death Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Cellular Response To BMP Stimulus Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Negative Regulation Of NIK/NF-kappaB Signaling Allantois Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Removal Of Superoxide Radicals	Epidermis Development Keratinization
Pathways		Molecules associated with elastic fibres	Keratinization
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cerebrospinal P-tau181p levels ( 28247064) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Metopic nonsyndromic craniosynostosis ( 32266521) Microalbuminuria in type 1 diabetes ( 31537649) Monobrow ( 27182965) Nose size ( 27182965) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Response to citalopram treatment ( 19846067) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) White blood cell types ( 21738478)
Interacting Genes		32 interacting genes: ACTN4 ACVR1 ACVR2A ACVR2B BEGAIN BMPR1A BMPR1B BMPR2 CCDC125 CHRDL2 CYSRT1 ENG GDF7 KHDRBS2 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP3-1 KRTAP5-9 KRTAP9-8 MTUS2 NBPF19 NCOA3 NOG NOTCH2NLA SOSTDC1 TDGF1 TRIM27	196 interacting genes: ABHD17A ADAM12 ADAMTSL4 ADAMTSL5 ALDH3B1 ALPP ATG9A BEX2 BMP7 C10orf62 C11orf87 CATSPER1 CHIC2 CHRD CHRNG CKS1B CNNM3 COL8A1 COMT CRCT1 CREB5 CRH CRY2 CTNNBIP1 CTSZ CXCL16 CYSRT1 DCDC2 DHRS1 DMRT3 DNASE1L3 DOCK2 EMC7 ENKD1 ENPP7 FAH FAM124B FAM161A FAM74A4 FAM76B FLT3LG GGN GLP1R GLRX3 GNE GRN GSC2 HEY2 HHEX HLCS HOXA1 HOXB9 HPCAL1 HSD3B7 HSPD1 IGFBP6 JOSD1 KLHL38 KLK8 KPRP KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 LY6H MAPKBP1 MEOX2 MOBP MT1M NAXD NBPF19 NCLN NECTIN2 NECTIN3 NKD1 NLK NMU NOTCH2NLA NPBWR2 NPDC1 NR4A3 NTAQ1 NTM NTN4 NUFIP2 OTX1 P2RX4 P2RY6 P4HB PCSK5 PDE9A PFKL PGAP6 PGLS PHLDA1 PIN1 POM121L8P POTEB3 POU4F2 PRKAB2 PSMA1 PTPMT1 RAMP3 RASD1 RGS20 RNF111 SCARB1 SCNM1 SDC3 SDCBP SEMA3B SHFL SLC13A5 SLC15A3 SLC22A23 SLC25A10 SMCP SPATA3 SPATC1L SPG7 SPINK2 SPRY1 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TGM1 TOMM22 TRARG1 TYRO3 UBE2I UXT VWC2 WNT11 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF581 ZNF587 ZNF655 ZNF696 ZNF837
Entrez ID		655	3846
HPRD ID		00212	01008
Ensembl ID		ENSG00000101144	ENSG00000254997
Uniprot IDs		A8K571 P18075	P26371
PDB IDs		1BMP 1LX5 1LXI 1M4U
Enriched GO Terms of Interacting Partners?
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