LBX1 and WNK3

Data Source:
BioGRID (two hybrid)

		LBX1	WNK3
Description		ladybird homeobox 1	WNK lysine deficient protein kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Cytoplasm Cytosol Adherens Junction Bicellular Tight Junction
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Heart Looping Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Spinal Cord Motor Neuron Differentiation Negative Regulation Of Neuron Differentiation Neuron Fate Determination	Protein Phosphorylation Cell Volume Homeostasis Osmosensory Signaling Pathway Positive Regulation Of Sodium Ion Transport Negative Regulation Of Sodium Ion Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Blood-brain Barrier Negative Regulation Of Apoptotic Process Protein Autophosphorylation Ion Homeostasis Positive Regulation Of Calcium Ion Transport Protein Localization To Plasma Membrane Regulation Of Calcium Ion Import Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cation Transmembrane Transport Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Stimuli-sensing channels
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091 26211971 30395268) Metabolite levels ( 23823483) Refractive error ( 32231278) Scoliosis ( 22019779)	Height ( 28552196)
Interacting Genes		23 interacting genes: AIPL1 DES EFEMP2 EIF5A FAM221B FAM9B IQGAP1 KANK2 KIF5B KIFC3 KRTAP5-6 KRTAP9-2 MAB21L3 PHF1 PRPF31 QRICH1 RBL2 TBCEL TMEM252 TSSK3 UBTFL1 WNK3 ZNF483	4 interacting genes: KLHL3 LBX1 REL TSC22D2
Entrez ID		10660	65267
HPRD ID		09178	02289
Ensembl ID		ENSG00000138136	ENSG00000196632
Uniprot IDs		P52954	Q9BYP7
PDB IDs			5NKP 5O1V 5O21 5O23 5O26 5O2B 5O2C
Enriched GO Terms of Interacting Partners?
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