HADH and ADH1A

Data Source:
BioGRID (two hybrid)

		HADH	ADH1A
Description		hydroxyacyl-CoA dehydrogenase	alcohol dehydrogenase 1A (class I), alpha polypeptide
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	3-hydroxyacyl-CoA Dehydrogenase Activity Transferase Activity Identical Protein Binding NAD+ Binding	Alcohol Dehydrogenase Activity, Zinc-dependent Retinol Dehydrogenase Activity Protein Binding Zinc Ion Binding
	Biological Process	Fatty Acid Beta-oxidation Regulation Of Insulin Secretion Positive Regulation Of Cold-induced Thermogenesis	Alcohol Metabolic Process Ethanol Oxidation Drug Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA	Abacavir metabolism RA biosynthesis pathway Ethanol oxidation
Drugs		NADH Acetoacetyl-CoA 3-Hydroxybutyryl-Coenzyme A Omega-3-carboxylic acids	NADH Fomepizole 4-Iodopyrazole N-Cyclopentyl-N-Cyclobutylformamide
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757)	Alcohol consumption (drinks per week) ( 30643258) Alcohol dependence ( 23456092) Regular attendance at a pub or social club ( 29970889) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		8 interacting genes: ADH1A APP CDC42 CLK1 FBXL17 FBXO7 SLC2A4 STAT1	2 interacting genes: CSNK2A2 HADH
Entrez ID		3033	124
HPRD ID		08372	00063
Ensembl ID		ENSG00000138796	ENSG00000187758
Uniprot IDs		A0A140VK76 B3KTT6 Q16836	P07327
PDB IDs		1F0Y 1F12 1F14 1F17 1IL0 1LSJ 1LSO 1M75 1M76 2HDH 3HAD 3RQS	1HSO 1U3T
Enriched GO Terms of Interacting Partners?
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