ARV1 and SCN3B

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ARV1	SCN3B
Description		ARV1 homolog, fatty acid homeostasis modulator	sodium voltage-gated channel beta subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Cortical Endoplasmic Reticulum	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc
	Molecular Function	Protein Binding Sterol Transporter Activity	Voltage-gated Ion Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Sphingolipid Metabolic Process Cholesterol Biosynthetic Process Sterol Metabolic Process Intracellular Sterol Transport Regulation Of Intracellular Cholesterol Transport Regulation Of Cholesterol Metabolic Process Regulation Of Plasma Membrane Sterol Distribution	Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Sensory Perception Of Pain Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Cholesterol biosynthesis	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases			Brugada syndrome (BRS)
GWAS		Metabolite levels ( 23823483)	Chronic lymphocytic leukemia ( 28165464 24292274 23770605) Response to citalopram or escitalopram in depression ( 27622933)
Interacting Genes		15 interacting genes: ADRB2 AQP6 CREB3L1 EBP FAM209A GPR152 MUC1 RNASEK SCN3B SLC10A6 SMO TLCD4 TMEM14B TMEM31 TMX2	105 interacting genes: ADIPOQ AGPAT4 AGPAT5 ANKRD46 AQP10 ARV1 ATP13A1 ATP6V0C BNIP1 BNIP3 BRICD5 CLCA4 CTXN3 CYP4F2 DEFB103A DEFB103B DERL1 DGAT2L6 ERG28 FAM241B FAM3C FIS1 FKBP8 FXYD3 GIMAP1 GIMAP5 GPR151 GPR61 IER3IP1 INSIG2 ISM2 ITGAM LEMD1 LEPROTL1 LPAR3 MAL2 MARCHF2 MFSD5 MGST3 MS4A13 NFASC NINJ2 ORMDL1 ORMDL2 PLBD2 PLP2 PLPPR2 PMP22 RHD RNF8 RUSF1 SACM1L SCD SEC22A SERP2 SFT2D1 SFXN1 SFXN3 SLC2A5 SLC30A3 SLC30A8 SLC35A4 SLC35E4 SLC38A1 SLC38A7 SLC7A1 SMCO4 SMIM1 STRIT1 STX3 STX6 STX8 THSD7A TIMM23 TM6SF2 TMBIM6 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM208 TMEM239 TMEM243 TMEM42 TMEM50B TMEM60 TMEM65 TMEM86A TMPPE TPRG1 TRARG1 TSPAN2 TVP23B UBIAD1 USE1 VAMP1 VAMP2 VAMP3 VAPA VAPB YIF1A YIPF4 ZFPL1
Entrez ID		64801	55800
HPRD ID		12494	10497
Ensembl ID		ENSG00000173409	ENSG00000166257
Uniprot IDs		A0A024R3V6 Q9H2C2	A0A024R3H7 Q9NY72
PDB IDs			4L1D
Enriched GO Terms of Interacting Partners?
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