ST6GAL1 and CD22

Data Source:
HPRD (in vitro)

		ST6GAL1	CD22
Description		ST6 beta-galactoside alpha-2,6-sialyltransferase 1	CD22 molecule
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane	Cytoplasm Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome
	Molecular Function	Beta-galactoside Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Protein Homodimerization Activity	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding
	Biological Process	N-acetylneuraminate Metabolic Process Humoral Immune Response O-glycan Processing Protein N-linked Glycosylation Via Asparagine Sialylation	Negative Regulation Of Immunoglobulin Production Cell Adhesion Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway
Pathways		Sialic acid metabolism Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Epratuzumab Inotuzumab ozogamicin Moxetumomab Pasudotox
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Albumin-globulin ratio ( 29403010) Blood protein levels ( 29875488) Drug-induced liver injury (flucloxacillin) ( 19483685) Eosinophil percentage of white cells ( 32888494) Esophageal cancer (squamous cell) ( 22960999) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA nephropathy ( 26028593) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG monosialylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 32888494) N-glycan levels ( 31163085) Non-albumin protein levels ( 29403010) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Thyroglobulin plasma levels ( 30929638) Type 2 diabetes ( 30054458 21874001 30297969 32499647 30718926)	Red cell distribution width ( 32888494)
Interacting Genes		1 interacting genes: CD22	20 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140
Entrez ID		6480	933
HPRD ID		00184	00114
Ensembl ID		ENSG00000073849	ENSG00000012124
Uniprot IDs		P15907	P20273 Q0EAF5
PDB IDs		4JS1 4JS2 6QVS 6QVT	5VKJ 5VKM 5VL3
Enriched GO Terms of Interacting Partners?
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