CD22 and ATP2B4

Data Source:
HPRD (in vitro, in vivo)

		CD22	ATP2B4
Description		CD22 molecule	ATPase plasma membrane Ca2+ transporting 4
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GO Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Basolateral Plasma Membrane Z Disc T-tubule Protein-containing Complex Sperm Flagellum Neuron Projection Intracellular Membrane-bounded Organelle Membrane Raft Sperm Principal Piece Glutamatergic Synapse Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Sodium Channel Regulator Activity ATPase-coupled Cation Transmembrane Transporter Activity Protein Kinase Binding PDZ Domain Binding Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Calcium-dependent Protein Binding Nitric-oxide Synthase Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Cell Adhesion Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway	Neural Retina Development Regulation Of Transcription By RNA Polymerase II Cellular Calcium Ion Homeostasis Spermatogenesis Negative Regulation Of Gene Expression Negative Regulation Of Nitric Oxide Mediated Signal Transduction Urinary Bladder Smooth Muscle Contraction Negative Regulation Of Angiogenesis Hippocampus Development Flagellated Sperm Motility Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Cytosolic Calcium Ion Concentration Response To Hydrostatic Pressure Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Transport Across Blood-brain Barrier Negative Regulation Of Arginine Catabolic Process Calcium Ion Export Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Regulation Of Cardiac Conduction Cellular Response To Acetylcholine Positive Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs		Epratuzumab Inotuzumab ozogamicin Moxetumomab Pasudotox	Halothane Desflurane
Diseases
GWAS		Red cell distribution width ( 32888494)	Breast size ( 22747683) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494 27863252) Malaria ( 22895189 31844061) Mean corpuscular hemoglobin concentration ( 23263863 32888494 28453575 27863252) Mean corpuscular volume ( 32888494 27863252) Monocyte count ( 32888494) Obstructive sleep apnea (average oxygen saturation during sleep) ( 26977737) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140	11 interacting genes: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBIN NOS1 PPP3CA RASSF1 SRC
Entrez ID		933	493
HPRD ID		00114	00159
Ensembl ID		ENSG00000012124	ENSG00000058668
Uniprot IDs		P20273 Q0EAF5	A0A024R968 P23634
PDB IDs		5VKJ 5VKM 5VL3	1CFF 2KNE
Enriched GO Terms of Interacting Partners?
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