AEN and RPGRIP1

Data Source:
BioGRID (two hybrid)

		AEN	RPGRIP1
Description		apoptosis enhancing nuclease	RPGR interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane	Axoneme Photoreceptor Connecting Cilium Ciliary Transition Zone Photoreceptor Distal Connecting Cilium
	Molecular Function	Nucleic Acid Binding Exonuclease Activity Protein Binding	Protein Binding
	Biological Process	Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Nucleic Acid Phosphodiester Bond Hydrolysis	Visual Perception Retinal Rod Cell Development Response To Stimulus Neural Precursor Cell Proliferation Non-motile Cilium Assembly
Pathways
Drugs
Diseases			Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Dupuytren's disease ( 28886342) Night sleep phenotypes ( 27126917)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		37 interacting genes: AAMP EMD EXOSC8 GNPTAB HAP1 HOMEZ IKZF1 KANK2 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 LZTS2 MBNL1 MID2 MTUS2 NKX3-1 PDE4DIP PHC2 RALYL RBMY1A1 RBMY1F RPGRIP1 SPOP SSX2IP TLE5 TRIM27 TRIM41 ZBTB43 ZBTB8A ZFP64 ZNF317 ZNF408 ZNF473	26 interacting genes: AEN BRCA1 CBX8 CCDC146 CHCHD3 CSPP1 DPPA4 FAM74A4 FEM1C GATAD2B HEYL IQCE MAGEB2 NPHP4 PTF1A RNF6 RPGR RPP25L SCNM1 TBC1D7 TFPT TRIB3 ZNF337 ZNF417 ZNF564 ZNF688
Entrez ID		64782	57096
HPRD ID		08573	05673
Ensembl ID		ENSG00000181026	ENSG00000092200
Uniprot IDs		Q8WTP8	Q96KN7
PDB IDs			4QAM
Enriched GO Terms of Interacting Partners?
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