SFTPD and LBR

Data Source:
BioGRID (proximity labelling technology)

		SFTPD	LBR
Description		surfactant protein D	lamin B receptor
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Endocytic Vesicle Clathrin-coated Endocytic Vesicle	Nucleus Nuclear Envelope Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Protein Binding Carbohydrate Binding	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding
	Biological Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Induction Of Bacterial Agglutination Cellular Protein Metabolic Process Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Regulation Of Immune Response Negative Regulation By Host Of Symbiont Molecular Function Reactive Oxygen Species Metabolic Process Regulation Of Adhesion Of Symbiont To Host Epithelial Cell	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Neutrophil Differentiation
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation Regulation of MECP2 expression and activity
Drugs		Beta-D-Glucose
Diseases			HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 30423114 24390342)	Delirium ( 29631748) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		3 interacting genes: DCN DMBT1 MFAP4	12 interacting genes: AKAP8L CBX3 CBX5 CD81 FNBP4 H4C14 LMNB1 MECP2 PRM1 SRPK1 SRPK2 YWHAG
Entrez ID		6441	3930
HPRD ID		01522	02488
Ensembl ID		ENSG00000133661	ENSG00000143815
Uniprot IDs		P35247	Q14739
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS	2DIG
Enriched GO Terms of Interacting Partners?
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